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Protein Regulatory Pathways
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Transcription_NF-kB signaling pathway [score: 1 (0%)]
The Nuclear factor kappa B (NF-kB) plays a crucial role
in immune and inflammatory responses through the regulation of genes encoding
pro-inflammatory cytokines, adhesion molecules, chemokines, growth factors and inducible
enzymes. Transcription factors of the NF-kB family are
activated ...
Immune response_IL-2 activation and signaling pathway [score: 1 (0%)]
Interleukin-2 (IL-2) is a T-Cell-derived cytokine
important in the regulation of growth and differentiation of T-Cells, B-Cells, natural
killer cells, glioma cells, and cells of the monocyte lineage.
IL-2 signaling is mediated by a multichain
IL-2 receptor complex consisting ...
Immune response_IL-4 signaling pathway [score: 1 (0%)]
Interleukin-4 (IL-4) is a T cell derived multifunctional
cytokine that plays a critical role in the regulation of immune responses.
IL-4 induces Th2 (T helper 2) differentiation, causes
macrophage suppression, and stimulates B cell production of Immunoglobulins E, G1 and G4
(IgE, ...
Immune response _IFN gamma signaling pathway [score: 1 (0%)]
Interferons (IFNs) are pleiotropic cytokines that mediate anti-viral responses,
inhibit proliferation and participate in immune surveillance and tumor suppression by
inducing the transcription of a number of IFN-stimulated genes. The IFN family includes
two main classes of related cytokines, type ...
Immune response_T cell receptor signaling pathway [score: 1 (0%)]
T cell receptors (TCR) play a key role in functioning of
T cells and formation of the immunological synapse. It provides connection between T cell
and the antigen-presenting cell (APC) [1]. TCRs are composed of
ligand-binding subunits, the alpha and beta chains, ...
Immune response_Alternative complement pathway [score: 1 (0%)]
Complement system is a major effector of humoral branch of the immune system, acting
to protect the host from microorganisms, such as bacteria.
Complement components are designated either by numerals
(C1-C9), letter symbols (e.g.,
Complement factor I (Factor I)), or by ...
Immune response_IL-6 signaling pathway [score: 1 (0%)]
Interleukin-6 (IL-6) is a pleiotropic cytokine produced
by various types of lymphoid and nonlymphoid cells, such as T cells, B cells, monocytes,
fibroblasts, keratinocytes, endothelial cells, mesangial cells and several tumor cells.
IL-6 provokes a broad range of cellular and physiological
responses, ...
Development_Notch Signaling Pathway [score: 1 (0%)]
Notch homolog 1 translocation-associated (NOTCH1) is
synthesized as NOTCH1 precursor, which is cleaved by
Furin to NOTCH1
receptor form. NOTCH1 receptor
is activated by Jagged [1]. O-fucosylpeptide
3-beta-N-acetylglucosaminyltransferase ...
Development_NOTCH1-mediated pathway for NF-KB activity modulation [score: 1 (0%)]
Interleukin 1 (IL-1) activates Nuclear factor of kappa
light polypeptide gene enhancer in B-cells (NF-KB) via
Interleukin-1 receptor-associated kinase (IRAK) and
Mitogen-activated protein kinase kinase kinase 1
(MEKK1(MAP3K1))-dependent inhibition of nuclear factor of
kappa ...
Immune response_MIF in innate immunity response [score: 1 (0%)]
The cytokine Macrophage migration inhibitory factor (MIF)
is an integral mediator of the innate immune system. Monocytes, macrophages and
lymphocytes constitutively express MIF, which is rapidly
released after exposure to bacterial toxins and cytokines.
MIF exerts potent proinflammatory ...
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