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Immune response_Role of integrins in NK cells cytotoxicity [score: 1 (0%)]
Natural killer (NK) cells are lymphocytes of innate immune system. They recognize and
kill aberrant cells without immunization or pre-activation, by releasing cytotoxic
granules and rapidly produce soluble factors - chemokines and cytokines.
NK cells feature a variety of cell surface receptors, ...
Development_Flt3 signaling [score: 1 (0%)]
FMS-like tyrosine kinase 3 (FLT3) belongs to the
subclass III family of receptor tyrosine kinases and it is expressed mainly in early
myeloid and lymphoid progenitor cells. Its activation leads mainly to proliferation and
survival [1], [2]. ...
Immune response_CD16 signaling in NK cells [score: 1 (0%)]
Natural killer (NK) cells mediate antibody-depend cellular cytotoxicity through the Fc
fragment of IgG, low affinity IIIa and receptor (CD16a) (Fc gamma RIII
alpha (CD16)) [1], [2]. The preferred ligands
for Fc gamma RIII alpha (CD16) ...
Development_Endothelin-1/EDNRA transactivation of EGFR [score: 1 (0%)]
Endothelin-1, a potent endothelium-derived
vasoconstrictor peptide, exerts a growth-promoting effect on vascular smooth muscle
cells, implicating its pathogenic role in vascular remodeling.
Endothelin-1 action is initiated by its binding to
Endothelin receptor type A (EDNRA) ...
Development_Endothelin-1/EDNRA signaling [score: 1 (0%)]
Endothelin-1, a potent endothelium-derived
vasoconstrictor peptide, exerts a growth-promoting effect on vascular smooth muscle
cells, implicating its pathogenic role in vascular remodeling.
Endothelin-1 action is exerted by its binding to Endothelin
receptor type A (EDNRA) [
Cytokine production by Th17 cells in CF [score: 1 (0%)]
Cystic Fibrosis (CF) is a potentially lethal genetic disease that typically results in
the development of bronchial inflammation, bronchiectasis, the progressive loss of lung
function and, ultimately, death [1].
CF is caused by genetic defects in Cystic Fibrosis ...
Immune response_Bacterial infections in normal airways [score: 1 (0%)]
The upper airways represent a primary site for the introduction of pathogenic
microorganisms from inspired air. The ciliated epithelium features several powerful
mechanisms for prevention of colonization by inhaled bacteria, thus the lower respiratory
tract usually remains sterile. Toll-like receptors ...
Selected targets of SP1 [score: 1 (0%)]
Sp1 transcription factor (SP1) is a transcription factor
involved in gene expression in the early development of an organism. It belongs to the
Sp/KLF family of transcription factors. The SP1
transcription factor contains a zinc finger protein motif, by which it binds directly to
DNA ...
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