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Regulatory Processes
Diseases
Protein Regulatory Pathways
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Apoptosis and survival_Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway [score: 1 (0%)]
The members of the tumour necrosis factor ligand family (TNFs) may induce both
apoptotic and anti-apoptotic pathways. TNFs transduces cellular responses through
activation of different TNF-receptors (TNFRs).
One important mechanism of cell survival is the activation of transcription of
different ...
Apoptosis and survival_Anti-apoptotic TNFs/NF-kB/IAP pathway [score: 1 (0%)]
Members of the tumour necrosis factor ligand family (TNFs) may induce both apoptotic
and anti-apoptotic pathways. TNFs transduces cellular responses through activation of
different TNF-receptors (TNFRs).
One important mechanism of cell survival is activation of transcription of different
anti-apoptotic ...
Immune response _CCR3 signaling in eosinophils [score: 1 (0%)]
Human eosinophils are key effector cells implicated in a number of chronic
inflammatory reactions, associated with bronchial asthma, allergic-inflammatory diseases
and parasitic infections. Chemoattractants/chemokines, generated at the affected sites,
promote migration of eosinophils from vasculature ...
Development_EPO-induced Jak-STAT pathway [score: 1 (0%)]
Erythropoiesis is a major pathway by which a pluripotent hematopoietic stem cell gives
rise to mature end stage cells. Erythropoietin (EPO) is a
lineage-specific hematopoietic growth factor required for survival, proliferation and
differentiation of committed erythroid progenitor cells [
Development_EPO-induced MAPK pathway [score: 1 (0%)]
Erythropoiesis is the main pathway of pluripotent hematopoietic stem cell development
into mature end stage cells. Erythropoietin (Epo) is a major
lineage-specific hematopoietic growth factor required for survival, proliferation and
differentiation of committed erythroid progenitor cells [
Apoptosis and survival_Lymphotoxin-beta receptor signaling [score: 1 (0%)]
Lymphotoxin-beta receptor (LTBR), a member of the tumor
necrosis factor receptor superfamily, is essential for the development and organization
of secondary lymphoid tissue. The LTBR binds specific
ligands, such as the membrane form of lymphotoxin heterotrimer, Lymphotoxin-Alpha1Beta2
(TNF-beta/LTB ...
Immune response_MIF-mediated glucocorticoid regulation [score: 1 (0%)]
Glucocorticoids are potent anti-inflammatory and
immunosuppressive agents. They inhibit synthesis of almost all known cytokines, enzymes
involved in the inflammatory process and several cell surface molecules required for
immune function. Glucocorticoids mediate these effects via
the ...
Immune response_Antigen presentation by MHC class I [score: 1 (0%)]
Antigen processing and presentation is the process by
which antigen-presenting cells express antigen on their cell
surface in a form recognizable by lymphocytes.
Antigen processing includes protein fragmentation
(proteolysis), association of the fragments with MHC (major ...
Immune response_Oncostatin M signaling via MAPK in human cells [score: 1 (0%)]
Oncostatin M is a multifunctional cytokine produced by
activated T lymphocytes, monocytes and microglia. It is structurally and functionally
related to the subfamily of hematopoietic and neurotrophic cytokines known as the
Interleukin 6 (IL6)-type cytokine family [1].
Human ...
Immune response_Oncostatin M signaling via JAK-Stat in human cells [score: 1 (0%)]
Oncostatin M is a multifunctional cytokine produced by
activated T lymphocytes, monocytes, microglia. It is structurally and functionally
related to the subfamily of hematopoietic and neurotrophic cytokines known as the
Interleukin 6 (IL6)-type cytokine family [1].
Human ...
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