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Regulatory Processes
Diseases
Protein Regulatory Pathways
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Immune response_MIF-JAB1 signaling [score: 1 (0%)]
Macrophage migration inhibitory factor (MIF) is a
pluripotent cytokine involved in inflammation and immune responses as well as in growth
factor-dependent cell proliferation, cell cycle, angiogenesis, and tumorigenesis [1], [2], [3], ...
Immune response_IL-22 signaling pathway [score: 1 (0%)]
Interleukin-22 (IL-22) is a member of the IL-10 family of
cytokines. The major sources of IL-22 are activated T cells,
especially upon type 1 polarization, and natural killer (NK) cells [1], [2].
IL-22 acts via a ...
Immune response_IL-9 signaling pathway [score: 1 (0%)]
Interleukin-9 (IL-9) is a multifunctional cytokine
secreted by T helper 2 (Th2) lymphocytes. IL-9 exerts
various effects on a variety of cell types associated with allergic inflammation.
IL-9 stimulates the growth and proliferation of T cells,
enhances the production of IgE from ...
Immune response_IL-10 signaling pathway [score: 1 (0%)]
Interleukin-10 (IL-10) is a pleiotropic cytokine with
important immunoregulatory functions. Its actions influence activities of many of the
cell-types in the immune system. It is also a cytokine with potent anti-inflammatory
properties: it represses the expression of inflammatory cytokines, ...
Immune response_Function of MEF2 in T lymphocytes [score: 1 (0%)]
Myocyte enhancer factors 2 (MEF2) is a family of
muscle-enriched transcription factors that have an essential role in myogenesis. In
addition, MEF2 is also expressed at high levels in neurons
and lymphocytes, where it serves as a regulator of neuronal and immune cell
differentiation ...
Immune response_TLR signaling pathways [score: 1 (0%)]
Both gram-positive and gram-negative bacteria and their cell wall components activate
innate immune system of the host and induce secretion of proinflammatory molecules,
mainly chemokines and cytokines [1]. Toll-like receptors (TLRs) initiate
signaling cascades through ...
Development_Thrombopoietin-regulated cell processes [score: 1 (0%)]
Thrombopoietin is a hormone involved in biological
effects on a broad spectrum of hematopoietic progenitor cells, including stem cells. It
supports stem cell survival and expansion. It is primarily a key physiological regulator
of steady-state megakaryocytopoiesis, the process of megakaryocyte ...
Immune response_BCR pathway [score: 1 (0%)]
The BCR (B-Cell antigen Receptor) plays a critical role in development, survival, and
activation of B lymphocytes. The BCR is composed of membrane immunoglobulin
(IgM) molecules associated with CD79a molecule,
immunoglobulin-associated alpha - CD79b molecule, immunoglobulin-associated beta
heterodimers ...
Immune response_IL-1 signaling pathway [score: 1 (0%)]
Interleukin-1 (IL-1) is a proinflammatory cytokine produced by activated macrophages,
endothelial cells, B cells and fibroblasts. IL-1 stimulates a broad spectrum of immune
and inflammatory responses [1], [2].
There are two forms of ...
Immune response_Lectin induced complement pathway [score: 1 (0%)]
The complement system is the major effector of the humoral branch of the immune
system, acting to protect the host from microorganisms such as bacteria.
Complement components are designated by numerals
(C1-C9), by letter symbols
(e.g., Complement factor I (Factor I)), ...
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