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Protein Regulatory Pathways
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Immune response_IL-2 activation and signaling pathway [score: 1 (0%)]
Interleukin-2 (IL-2) is a T-Cell-derived cytokine
important in the regulation of growth and differentiation of T-Cells, B-Cells, natural
killer cells, glioma cells, and cells of the monocyte lineage.
IL-2 signaling is mediated by a multichain
IL-2 receptor complex consisting ...
Immune response_IL-4 signaling pathway [score: 1 (0%)]
Interleukin-4 (IL-4) is a T cell derived multifunctional
cytokine that plays a critical role in the regulation of immune responses.
IL-4 induces Th2 (T helper 2) differentiation, causes
macrophage suppression, and stimulates B cell production of Immunoglobulins E, G1 and G4
(IgE, ...
Immune response _IFN gamma signaling pathway [score: 1 (0%)]
Interferons (IFNs) are pleiotropic cytokines that mediate anti-viral responses,
inhibit proliferation and participate in immune surveillance and tumor suppression by
inducing the transcription of a number of IFN-stimulated genes. The IFN family includes
two main classes of related cytokines, type ...
Development_EGFR signaling pathway [score: 1 (0%)]
Epidermal growth factor receptor (EGFR) belongs to the
ERBB family of receptor tyrosine kinases that contains four
closely related members EGFR and ERBB2-4. They couple the
binding of the extracellular growth factor ligands to intracellular signaling pathways
that regulate diverse ...
Development_HGF signaling pathway [score: 1 (0%)]
Hepatocyte growth factor/Scatter factor (HGF) is a
multifunctional growth factor which induces cell dissociation, migration, protection from
apoptosis, proliferation and differentiation [1]. Receptor Met
proto-oncogene (HGF receptor (Met))
has tyrosine-kinase ...
Immune response_IL-10 signaling pathway [score: 1 (0%)]
Interleukin-10 (IL-10) is a pleiotropic cytokine with
important immunoregulatory functions. Its actions influence activities of many of the
cell-types in the immune system. It is also a cytokine with potent anti-inflammatory
properties: it represses the expression of inflammatory cytokines, ...
Development_ERBB-family signaling [score: 1 (0%)]
The ERBB family of receptor tyrosine kinases consists of
four closely related members: Epidermal growth factor receptor
(EGFR, also known as ERBB1), v-erb-b2 erythroblastic
leukemia viral oncogene homolog 2, 3 and 4 (ERBB2,
ERBB3, and ERBB4). Binding of
extracellular ...
Development_Thrombopoietin-regulated cell processes [score: 1 (0%)]
Thrombopoietin is a hormone involved in biological
effects on a broad spectrum of hematopoietic progenitor cells, including stem cells. It
supports stem cell survival and expansion. It is primarily a key physiological regulator
of steady-state megakaryocytopoiesis, the process of megakaryocyte ...
Cell adhesion_Plasmin signaling [score: 1 (0%)]
Plasmin is a major fibrinolytic protease
with wide substrate specificity.
Plasminogen, a circulating plasma zymogen,
can be converted to Plasmin by tissue-type Plasminogen
activator (PLAT), Plasminogen activator urokinase
(PLAU), Coagulation factor XII,
or ...
Cell adhesion_PLAU signaling [score: 1 (0%)]
The binding of Plasminogen activator, urokinase (PLAU
(UPA)) to its glycosyl-phosphatidyl-inositol (GPI) anchored Plasminogen
activator, urokinase receptor (PLAUR (UPAR) (uPAR)) mediates
a variety of functions including vascular homeostasis, inflammation and tissue repair
[1].
PLAU ...
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