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Regulatory Processes
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Protein Regulatory Pathways
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| Showing 1 - 9 out of 9 |
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Development_EGFR signaling pathway [score: 1 (0%)]
Epidermal growth factor receptor (EGFR) belongs to the
ERBB family of receptor tyrosine kinases that contains four
closely related members EGFR and ERBB2-4. They couple the
binding of the extracellular growth factor ligands to intracellular signaling pathways
that regulate diverse ...
Immune response_IL-6 signaling pathway [score: 1 (0%)]
Interleukin-6 (IL-6) is a pleiotropic cytokine produced
by various types of lymphoid and nonlymphoid cells, such as T cells, B cells, monocytes,
fibroblasts, keratinocytes, endothelial cells, mesangial cells and several tumor cells.
IL-6 provokes a broad range of cellular and physiological
responses, ...
Immune response_MIF in innate immunity response [score: 1 (0%)]
The cytokine Macrophage migration inhibitory factor (MIF)
is an integral mediator of the innate immune system. Monocytes, macrophages and
lymphocytes constitutively express MIF, which is rapidly
released after exposure to bacterial toxins and cytokines.
MIF exerts potent proinflammatory ...
Immune response_IL-22 signaling pathway [score: 1 (0%)]
Interleukin-22 (IL-22) is a member of the IL-10 family of
cytokines. The major sources of IL-22 are activated T cells,
especially upon type 1 polarization, and natural killer (NK) cells [1], [2].
IL-22 acts via a ...
Immune response_TLR signaling pathways [score: 1 (0%)]
Both gram-positive and gram-negative bacteria and their cell wall components activate
innate immune system of the host and induce secretion of proinflammatory molecules,
mainly chemokines and cytokines [1]. Toll-like receptors (TLRs) initiate
signaling cascades through ...
Immune response_IL-1 signaling pathway [score: 1 (0%)]
Interleukin-1 (IL-1) is a proinflammatory cytokine produced by activated macrophages,
endothelial cells, B cells and fibroblasts. IL-1 stimulates a broad spectrum of immune
and inflammatory responses [1], [2].
There are two forms of ...
Immune response_MIF-mediated glucocorticoid regulation [score: 1 (0%)]
Glucocorticoids are potent anti-inflammatory and
immunosuppressive agents. They inhibit synthesis of almost all known cytokines, enzymes
involved in the inflammatory process and several cell surface molecules required for
immune function. Glucocorticoids mediate these effects via
the ...
Apoptosis and survival_APRIL and BAFF signaling [score: 1 (0%)]
Tumor necrosis factor (ligand) superfamily members 13 and 13b (APRIL
and BAFF) and their receptors - Tumor
necrosis factor receptor superfamily members 13C, 17 and 13B
(BAFF-R, BCMA and
TACI) - play important roles in the B-cell and T-cell arms
of the immune system ...
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