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Immune response_IL-2 activation and signaling pathway [score: 1 (0%)]
Interleukin-2 (IL-2) is a T-Cell-derived cytokine
important in the regulation of growth and differentiation of T-Cells, B-Cells, natural
killer cells, glioma cells, and cells of the monocyte lineage.
IL-2 signaling is mediated by a multichain
IL-2 receptor complex consisting ...
Development_TGF-beta receptor signaling [score: 1 (0%)]
Transforming growth factor beta (TGF-beta) signaling
controls diverse cellular processes, including cell proliferation, differentiation,
adhesion and migration [1], [2], [3].
TGF-beta 1 initiates ...
Immune response_IL-6 signaling pathway [score: 1 (0%)]
Interleukin-6 (IL-6) is a pleiotropic cytokine produced
by various types of lymphoid and nonlymphoid cells, such as T cells, B cells, monocytes,
fibroblasts, keratinocytes, endothelial cells, mesangial cells and several tumor cells.
IL-6 provokes a broad range of cellular and physiological
responses, ...
Cytoskeleton remodeling_Reverse signaling by ephrin B [score: 1 (0%)]
Ephrin receptors and Ephrins
are both membrane bound, and following their interaction and clustering, each can
transduce signals that regulate cell responses [1].
Ephrin receptors activate reverse signaling through their
Ephrin ligands ...
Development_HGF signaling pathway [score: 1 (0%)]
Hepatocyte growth factor/Scatter factor (HGF) is a
multifunctional growth factor which induces cell dissociation, migration, protection from
apoptosis, proliferation and differentiation [1]. Receptor Met
proto-oncogene (HGF receptor (Met))
has tyrosine-kinase ...
Chemotaxis_CXCR4 signaling pathway [score: 1 (0%)]
Chemokine (C-X-C motif) receptor-4 (CXCR4) is a G
protein-coupled receptor (GPCR). It is the only known receptor for stromal-derived
factor-1 (SDF-1), and SDF-1 is
the only known ligand for CXCR4 [1].
The CXCR4 is expressed in ...
Cell adhesion_PLAU signaling [score: 1 (0%)]
The binding of Plasminogen activator, urokinase (PLAU
(UPA)) to its glycosyl-phosphatidyl-inositol (GPI) anchored Plasminogen
activator, urokinase receptor (PLAUR (UPAR) (uPAR)) mediates
a variety of functions including vascular homeostasis, inflammation and tissue repair
[1].
PLAU ...
Development_EGFR signaling via small GTPases [score: 1 (0%)]
The Epidermal growth factor receptor (EGFR) belongs to
the ERBB family of receptor tyrosine kinases, which consists of four closely related
members: EGFR and v-erb-b2 erythroblastic leukemia viral
oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
(ERBB2), ERBB3 ...
Immune response _CCR3 signaling in eosinophils [score: 1 (0%)]
Human eosinophils are key effector cells implicated in a number of chronic
inflammatory reactions, associated with bronchial asthma, allergic-inflammatory diseases
and parasitic infections. Chemoattractants/chemokines, generated at the affected sites,
promote migration of eosinophils from vasculature ...
Development_EPO-induced Jak-STAT pathway [score: 1 (0%)]
Erythropoiesis is a major pathway by which a pluripotent hematopoietic stem cell gives
rise to mature end stage cells. Erythropoietin (EPO) is a
lineage-specific hematopoietic growth factor required for survival, proliferation and
differentiation of committed erythroid progenitor cells [
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