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Immune response_Role of integrins in NK cells cytotoxicity [score: 1 (0%)]
Natural killer (NK) cells are lymphocytes of innate immune system. They recognize and
kill aberrant cells without immunization or pre-activation, by releasing cytotoxic
granules and rapidly produce soluble factors - chemokines and cytokines.
NK cells feature a variety of cell surface receptors, ...
Development_Flt3 signaling [score: 1 (0%)]
FMS-like tyrosine kinase 3 (FLT3) belongs to the
subclass III family of receptor tyrosine kinases and it is expressed mainly in early
myeloid and lymphoid progenitor cells. Its activation leads mainly to proliferation and
survival [1], [2]. ...
Immune response_CD16 signaling in NK cells [score: 1 (0%)]
Natural killer (NK) cells mediate antibody-depend cellular cytotoxicity through the Fc
fragment of IgG, low affinity IIIa and receptor (CD16a) (Fc gamma RIII
alpha (CD16)) [1], [2]. The preferred ligands
for Fc gamma RIII alpha (CD16) ...
Apoptosis and survival_APRIL and BAFF signaling [score: 1 (0%)]
Tumor necrosis factor (ligand) superfamily members 13 and 13b (APRIL
and BAFF) and their receptors - Tumor
necrosis factor receptor superfamily members 13C, 17 and 13B
(BAFF-R, BCMA and
TACI) - play important roles in the B-cell and T-cell arms
of the immune system ...
Blood coagulation [score: 1 (0%)]
The haemostatic system maintains blood in a fluid state under normal conditions and
responds to vessel injury by the rapid formation of a clot consisting of platelets and
Fibrin. The traditional view of the regulation of blood coagulation is that the
initiation phase is triggered by an extrinsic ...
Manganese, Calcium and Iron-regulated proteins [score: 1 (0%)]
Proteins, regulated by binding of inorganic ions, are very important for different
aspects of cell functioning.
There is a wide variety of Calcium, Manganese and Iron-regulated proteins inside and
out of the cells.
Binding of Ca('2+) extracellular region to receptors of
L-Glutamic ...
Selected targets of Androgen and Estrogen receptors [score: 1 (0%)]
Androgen and Estrogen receptors (Androgen receptor and
ESR1 (nuclear)) function as steroid-hormone activated
transcription factors. Upon binding the hormone ligand, receptors dissociate from
accessory proteins, translocate into the nucleus, dimerize, and then stimulate
transcription ...
Selected targets of NRSF [score: 1 (0%)]
RE1-silencing transcription factor (NRSF) is a member of
the Kruppel-type zinc finger transcription factor family. It is a transcriptional
repressor of neuronal genes in non-neuronal tissues. It represses transcription by
binding a DNA sequence element called the neuron-restrictive silencer ...
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