Prolactin is a polypeptide hormone secreted by the pituitary gland and to a lesser extent by numerous extrapituitary tissues. This hormone affects a great amount of physiological processes [1]. Numerous biological functions have been attributed to this hormone's ...

In addition to the conventional hormone-dependent regulation of activity of Estrogen receptor alpha and beta (ESR1(nuclear) and ESR2 respectively), there is a cross-talk between signal transduction pathways and estrogen receptors [1]. Epidermal growth factor (EGF), ...

Growth hormone (GH or Somatotropin) is a major growth-promoting and metabolic regulatory hormone. Interaction of Somatotropin with Growth hormone receptor (GHR), by virtue of receptor dimerization, causes activation of GHR associated cytoplasmic tyrosine kinase, Janus kinase ...

Subtype alpha-1 adrenergic receptors consists of Alpha-1A adrenergic receptor, Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor. They participate in many physiological processes via different pathways. One of the best studied alpha-1 adrenergic receptors-stimulated ...

Activins are the members of the Transforming growth factor beta (TGF-beta) superfamily which participate in regulation of several biological processes, including cell differentiation and cell ...

Androgen and Estrogen receptors (Androgen receptor and ESR1 (nuclear)) function as steroid-hormone activated transcription factors. Upon binding the hormone ligand, receptors dissociate from accessory proteins, translocate into the nucleus, dimerize, and then stimulate transcription ...

Sp1 transcription factor (SP1) is a transcription factor involved in gene expression in the early development of an organism. It belongs to the Sp/KLF family of transcription factors. The SP1 transcription factor contains a zinc finger protein motif, by which it binds directly to DNA ...

V-myc myelocytomatosis viral oncogene homolog (c-Myc) is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. c-Myc controls the transcription of a variety of different targets and regulates different processes, ...

cAMP responsive element binding protein 1 (CREB1) is a transcription factor that is a member of the leucine zipper family of DNA binding proteins. CREB1 binds as a homodimer to the cAMP-responsive element, an octameric palindrome. CREB1 is phosphorylated by several protein kinases, ...