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Development_Prolactin receptor signaling [score: 1 (0%)]
Prolactin is a polypeptide hormone secreted by the
pituitary gland and to a lesser extent by numerous extrapituitary tissues. This hormone
affects a great amount of physiological processes [1]. Numerous biological
functions have been attributed to this hormone's ...
Translation_Insulin regulation of translation [score: 1 (0%)]
Insulin plays an important role in the overall regulation
of protein synthesis. Protein synthesis (mRNA translation) is conventionally divided into
three stages: initiation, elongation and termination. Both initiation and elongation can
be controlled by Insulin.
Insulin ...
Regulation of lipid metabolism_Insulin signaling:generic cascades [score: 1 (0%)]
The binding of Insulin to the extracellular domain of the
Insulin receptor results in the activation of the tyrosine
kinase activity of the receptor. Following the autophosphorylation, the
Insulin receptor phosphorylates a number of intracellular
substrates to initiate a series ...
Androstenedione and testosterone biosynthesis and metabolism p.1 [score: 1 (0%)]
Androstenedione is a 19-carbon steroid hormone produced
as an intermediate step in the biochemical pathway that produces the androgen
Testosterone and the estrogens
Estrone and Estradiol.
Androstenedione originates either from the conversion of
Dehydroepiandrosterone ...
Estradiol metabolism [score: 1 (0%)]
Endogenous and exogenous estrogens undergo oxidative metabolism by hepatic microsomal
cytochrome P-450. Aromatic hydroxylation at either the C2 or C4 position is a major route
of Estradiol metabolism in humans and other mammals,
although there is less 4-hydroxylation than 2-hydroxylation. ...
Estrone metabolism [score: 1 (0%)]
Endogenous and exogenous estrogens undergo oxidative metabolism by hepatic microsomal
cytochrome P-450. Aromatic hydroxylation at either the C2 or C4 position is a major route
of Estrone metabolism in humans and other mammals, although
there are less 4-hydroxylation than 2-hydroxylation events. ...
Transcription_Androgen Receptor nuclear signaling [score: 1 (0%)]
Androgen is the active metabolic product,
5alpha-Dihydrotestosterone, which is produced from the
transformation of Testosterone catalyzed by the
Steroid-5-alpha-reductase, alpha polypeptides 1 and 2 (S5AR1
and S5AR2) [1], [2]. ...
Development_Ligand-independent activation of ESR1 and ESR2 [score: 1 (0%)]
In addition to the conventional hormone-dependent regulation of activity of Estrogen
receptor alpha and beta (ESR1(nuclear) and
ESR2 respectively), there is a cross-talk between signal transduction
pathways and estrogen receptors [1]. Epidermal growth factor
(EGF), ...
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