Ligand Dependent Transcription of Retinoid-Target
Retinoid receptors are asymmetrically oriented Retinoic acid receptor (RAR)/ Retinoid
X receptor (RXR) heterodimers that bind to specific DNA sequences or Retinoic acid
response elements (RAREs) in the promoters ...
Endogenous and exogenous estrogens undergo oxidative metabolism by hepatic microsomal
cytochrome P-450. Aromatic hydroxylation at either the C2 or C4 position is a major route
of Estradiol metabolism in humans and other mammals,
although there is less 4-hydroxylation ...