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Development_NOTCH1-mediated pathway for NF-KB activity modulation [score: 1 (0%)]
Interleukin 1 (IL-1) activates Nuclear factor of kappa
light polypeptide gene enhancer in B-cells (NF-KB) via
Interleukin-1 receptor-associated kinase (IRAK) and
Mitogen-activated protein kinase kinase kinase 1
(MEKK1(MAP3K1))-dependent inhibition of nuclear factor of
kappa ...
Cytoskeleton remodeling_Reverse signaling by ephrin B [score: 1 (0%)]
Ephrin receptors and Ephrins
are both membrane bound, and following their interaction and clustering, each can
transduce signals that regulate cell responses [1].
Ephrin receptors activate reverse signaling through their
Ephrin ligands ...
Transcription_PPAR Pathway [score: 1 (0%)]
Peroxisome Proliferator-Activated Receptors (PPAR) are
ligand-inducible transcription factors that belong to the nuclear hormone receptor
superfamily. The PPAR group consists of three types:
PPAR-alpha, PPAR-beta(delta)
and PPAR-gamma. They have some differences ...
Retinol metabolism [score: 1 (0%)]
Key enzymes involved in retinoid metabolisms are alcohol and aldehyde dehydrogenases
that convert retinols to aldehydes and aldehydes to carboxylic acids, respectively. The
first oxidation reaction is catalyzed by a large number of enzymes from the
Dehydrogenase/reductase (SDR family), and by classic ...
Glutathione metabolism [score: 1 (0%)]
Glutathione can be found in the cell in oxidized (Glutathione
disulfide) and reduced (Glutathione) form.
Reduced glutathione can be either directly formed from Glutathione
disulfide as the result of activity of Glutathione reductase
(GSHR) [1], ...
Naphthalene metabolism [score: 1 (0%)]
Toxicity of Naphthalene in cell culture and animal models
has to do with metabolisation of this compound by cytochrome P450 monooxygenases.
Deactivation of Naphthalene involves epoxidation followed by
glutathione conjugation and mercapturic acid formation [1].
Naphthalene ...
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