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G-protein signaling_N-RAS regulation pathway [score: 1 (0%)]
Neuroblastoma RAS viral (v-ras) oncogene homolog (N-RAS)
belongs to Ras family of small GTPases. It serves as a signal transducer from growth
factor receptors and activates numerous effector molecules resulting in cell growth,
differentiation and survival [1], [
DNA damage_ATM/ATR regulation of G1/S checkpoint [score: 1 (0%)]
DNA damage checkpoints are biochemical pathways that delay or arrest the cell cycle
progression in response to the DNA damage. All eukaryotic cells have four phases within
the cell cycle, G1, S, G2, and M, and one outside, G0 [1].
The G1/S checkpoint prevents cells ...
Immune response_IL-4 signaling pathway [score: 1 (0%)]
Interleukin-4 (IL-4) is a T cell derived multifunctional
cytokine that plays a critical role in the regulation of immune responses.
IL-4 induces Th2 (T helper 2) differentiation, causes
macrophage suppression, and stimulates B cell production of Immunoglobulins E, G1 and G4
(IgE, ...
Development_Angiotensin signaling via PYK2 [score: 1 (0%)]
Angiotensin II, a major effector peptide of the
renin-angiotensin system, is believed to play a critical role in the pathogenesis of
cardiovascular remodeling associated with hypertension, heart failure, and
atherosclerosis. [1]
Angiotensin II receptor, ...
Development_FGFR signaling pathway [score: 1 (0%)]
Fibroblast growth factor 2 (FGF2) has been implicated in
diverse cellular processes, including apoptosis, cell survival, chemotaxis, cell
adhesion, migration, differentiation, and proliferation [1].
FGF2 induces biological responses by binding to ...
Cell cycle_Regulation of G1/S transition (part 2) [score: 1 (0%)]
The commencement of the cell cycle coincides with the production and the stabilization
of the Cyclin D. The D-type cyclins are essential for
synchronization of the cell cycle machinery with extracellular signals. [1]
Expression and stability of Cyclin D is ...
Development_TGF-beta receptor signaling [score: 1 (0%)]
Transforming growth factor beta (TGF-beta) signaling
controls diverse cellular processes, including cell proliferation, differentiation,
adhesion and migration [1], [2], [3].
TGF-beta 1 initiates ...
Immune response_Alternative complement pathway [score: 1 (0%)]
Complement system is a major effector of humoral branch of the immune system, acting
to protect the host from microorganisms, such as bacteria.
Complement components are designated either by numerals
(C1-C9), letter symbols (e.g.,
Complement factor I (Factor I)), or by ...
Development_Notch Signaling Pathway [score: 1 (0%)]
Notch homolog 1 translocation-associated (NOTCH1) is
synthesized as NOTCH1 precursor, which is cleaved by
Furin to NOTCH1
receptor form. NOTCH1 receptor
is activated by Jagged [1]. O-fucosylpeptide
3-beta-N-acetylglucosaminyltransferase ...
Development_NOTCH1-mediated pathway for NF-KB activity modulation [score: 1 (0%)]
Interleukin 1 (IL-1) activates Nuclear factor of kappa
light polypeptide gene enhancer in B-cells (NF-KB) via
Interleukin-1 receptor-associated kinase (IRAK) and
Mitogen-activated protein kinase kinase kinase 1
(MEKK1(MAP3K1))-dependent inhibition of nuclear factor of
kappa ...
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