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Development_EPO-induced Jak-STAT pathway [score: 1 (0%)]
Erythropoiesis is a major pathway by which a pluripotent hematopoietic stem cell gives
rise to mature end stage cells. Erythropoietin (EPO) is a
lineage-specific hematopoietic growth factor required for survival, proliferation and
differentiation of committed erythroid progenitor cells [
Development_EPO-induced MAPK pathway [score: 1 (0%)]
Erythropoiesis is the main pathway of pluripotent hematopoietic stem cell development
into mature end stage cells. Erythropoietin (Epo) is a major
lineage-specific hematopoietic growth factor required for survival, proliferation and
differentiation of committed erythroid progenitor cells [
Tyrosine metabolism p.1 (dopamine) [score: 1 (0%)]
(L)-Tyrosine is a non-essential
aminoacid that is synthesized in mammals from
(L)-Phenylalanine by Phenylalanine hydroxylase
(PAH) [1].
(L)-Tyrosine, as other proteogenic aminoacids, conjugates
with corresponding tRNA forming ...
Glycolysis and gluconeogenesis (short map) [score: 1 (0%)]
D-Glucose is the major energy source for mammalian cells
as well as an important substrate for protein and lipid synthesis. Mammalian cells take
up D-Glucose from extracellular fluid into the cell through
two families of structurally related glucose transporters. Solute carrier family ...
Development_Slit-Robo signaling [score: 1 (0%)]
Attractive and repulsive receptors regulate cell motility and attachment in axon
guidance, vascular growth, immune cell regulation and tumor progression. There is strong
evidence that development of the nervous and vascular systems is controlled by common
cues.
Semaphorins, Ephrins, SLITs ...
Transcription_Androgen Receptor nuclear signaling [score: 1 (0%)]
Androgen is the active metabolic product,
5alpha-Dihydrotestosterone, which is produced from the
transformation of Testosterone catalyzed by the
Steroid-5-alpha-reductase, alpha polypeptides 1 and 2 (S5AR1
and S5AR2) [1], [2]. ...
Translation_Non-genomic (rapid) action of Androgen Receptor [score: 1 (0%)]
Androgen is the active metabolic product, 5alpha-Dihydrotestosterone
(DHT), which is produced from the transformation of
Testosterone catalyzed by the Steroid-5-alpha-reductase,
alpha polypeptides 1 and 2 (S5AR1 and
S5AR2) [1], [2]. ...
Development_Growth hormone signaling via PI3K/AKT and MAPK cascades [score: 1 (0%)]
Growth hormone (GH or Somatotropin) is a major
growth-promoting and metabolic regulatory hormone. Interaction of
Somatotropin with Growth hormone receptor
(GHR), by virtue of receptor dimerization, causes activation
of GHR associated cytoplasmic tyrosine kinase, Janus kinase ...
Cytokine production by Th17 cells in CF [score: 1 (0%)]
Cystic Fibrosis (CF) is a potentially lethal genetic disease that typically results in
the development of bronchial inflammation, bronchiectasis, the progressive loss of lung
function and, ultimately, death [1].
CF is caused by genetic defects in Cystic Fibrosis ...
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