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Protein Regulatory Pathways
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Immune response_IL-10 signaling pathway [score: 1 (0%)]
Interleukin-10 (IL-10) is a pleiotropic cytokine with
important immunoregulatory functions. Its actions influence activities of many of the
cell-types in the immune system. It is also a cytokine with potent anti-inflammatory
properties: it represses the expression of inflammatory cytokines, ...
Development_Prolactin receptor signaling [score: 1 (0%)]
Prolactin is a polypeptide hormone secreted by the
pituitary gland and to a lesser extent by numerous extrapituitary tissues. This hormone
affects a great amount of physiological processes [1]. Numerous biological
functions have been attributed to this hormone's ...
Chemotaxis_CXCR4 signaling pathway [score: 1 (0%)]
Chemokine (C-X-C motif) receptor-4 (CXCR4) is a G
protein-coupled receptor (GPCR). It is the only known receptor for stromal-derived
factor-1 (SDF-1), and SDF-1 is
the only known ligand for CXCR4 [1].
The CXCR4 is expressed in ...
Cell adhesion_Plasmin signaling [score: 1 (0%)]
Plasmin is a major fibrinolytic protease
with wide substrate specificity.
Plasminogen, a circulating plasma zymogen,
can be converted to Plasmin by tissue-type Plasminogen
activator (PLAT), Plasminogen activator urokinase
(PLAU), Coagulation factor XII,
or ...
Proteolysis_Role of Parkin in the Ubiquitin-Proteasomal Pathway [score: 1 (0%)]
Parkin is E3-ubiquitin-protein ligase that ubiquitinates
itself and specific substrate proteins playing a protective role by sequestering
misfolded proteins [1].
E3 ligases are part of the cellular machinery that tags proteins with ubiquitin,
thereby targeting ...
Immune response_Lectin induced complement pathway [score: 1 (0%)]
The complement system is the major effector of the humoral branch of the immune
system, acting to protect the host from microorganisms such as bacteria.
Complement components are designated by numerals
(C1-C9), by letter symbols
(e.g., Complement factor I (Factor I)), ...
Signal transduction_PTEN pathway [score: 1 (0%)]
Phosphatase and tensin homolog (PTEN) is a known tumor
suppressor. It inhibits growth factor-induced cell proliferation, division and regulates
Integrin-mediated cell adhesion and survival [1].
PTEN antagonizes Phosphoinositide-3-kinase
(PI3K), ...
Cell adhesion_PLAU signaling [score: 1 (0%)]
The binding of Plasminogen activator, urokinase (PLAU
(UPA)) to its glycosyl-phosphatidyl-inositol (GPI) anchored Plasminogen
activator, urokinase receptor (PLAUR (UPAR) (uPAR)) mediates
a variety of functions including vascular homeostasis, inflammation and tissue repair
[1].
PLAU ...
Translation_Insulin regulation of translation [score: 1 (0%)]
Insulin plays an important role in the overall regulation
of protein synthesis. Protein synthesis (mRNA translation) is conventionally divided into
three stages: initiation, elongation and termination. Both initiation and elongation can
be controlled by Insulin.
Insulin ...
Development_MAG-dependent inhibition of neurite outgrowth [score: 1 (0%)]
Neurotrophins are key regulators of the fate and shape of neuronal cells. They act as
guidance cues for growth cones by remodeling actin cytoskeleton. Neurotrophins
(NGF, BDNF,
NT-3 and NT-4/5) bind to two
structurally unrelated receptors, tyrosine kinase Trk receptors
(TrkA, ...
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