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Development_FGFR signaling pathway [score: 1 (0%)]
Fibroblast growth factor 2 (FGF2) has been implicated in
diverse cellular processes, including apoptosis, cell survival, chemotaxis, cell
adhesion, migration, differentiation, and proliferation [1].
FGF2 induces biological responses by binding to ...
Cytoskeleton remodeling_Reverse signaling by ephrin B [score: 1 (0%)]
Ephrin receptors and Ephrins
are both membrane bound, and following their interaction and clustering, each can
transduce signals that regulate cell responses [1].
Ephrin receptors activate reverse signaling through their
Ephrin ligands ...
Development_HGF signaling pathway [score: 1 (0%)]
Hepatocyte growth factor/Scatter factor (HGF) is a
multifunctional growth factor which induces cell dissociation, migration, protection from
apoptosis, proliferation and differentiation [1]. Receptor Met
proto-oncogene (HGF receptor (Met))
has tyrosine-kinase ...
Development_ERBB-family signaling [score: 1 (0%)]
The ERBB family of receptor tyrosine kinases consists of
four closely related members: Epidermal growth factor receptor
(EGFR, also known as ERBB1), v-erb-b2 erythroblastic
leukemia viral oncogene homolog 2, 3 and 4 (ERBB2,
ERBB3, and ERBB4). Binding of
extracellular ...
Development_IGF-1 receptor signaling [score: 1 (0%)]
The insulin-like growth factor system (IGF system) comprises two receptors:
Insulin-like growth factor 1 receptor (IGF-1 receptor) and
IGF-IIR with their respective ligands: Insulin-like growth factors 1 and 2
(IGF-1 and IGF-2) and six
high-affinity IGF binding proteins (IBP).
The ...
Chemotaxis_CXCR4 signaling pathway [score: 1 (0%)]
Chemokine (C-X-C motif) receptor-4 (CXCR4) is a G
protein-coupled receptor (GPCR). It is the only known receptor for stromal-derived
factor-1 (SDF-1), and SDF-1 is
the only known ligand for CXCR4 [1].
The CXCR4 is expressed in ...
Development_EGFR signaling via PIP3 [score: 1 (0%)]
The Epidermal growth factor receptor (EGFR) belongs to
the ERBB family of receptor tyrosine kinases, which consists of four closely related
members: EGFR and v-erb-b2 erythroblastic leukemia viral
oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
(ERBB2), ERBB3 ...
Development_EGFR signaling via small GTPases [score: 1 (0%)]
The Epidermal growth factor receptor (EGFR) belongs to
the ERBB family of receptor tyrosine kinases, which consists of four closely related
members: EGFR and v-erb-b2 erythroblastic leukemia viral
oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
(ERBB2), ERBB3 ...
Cell adhesion_ECM remodeling [score: 1 (0%)]
Extracellular matrix (ECM) remodeling is involved in normal physiological processes,
such as embryonic development, reproduction, proliferation, cell motility and adhesion,
wound healing, angiogenesis, as well as in disease processes, such as arthritis and
metastasis. Matrix metalloproteinases (MMPs) ...
Cell adhesion_Endothelial cell contacts by non-junctional mechanisms [score: 1 (0%)]
Contacts between endothelial cells are of great importance for blood vessel
formation. The formation and maintenance of endothelial cell
contacts require the complex interplay of plasma membrane proteins, cytoskeleton
components, and signaling molecules. Some of these molecules are specifically ...
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