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Development_Prolactin receptor signaling [score: 1 (0%)]
Prolactin is a polypeptide hormone secreted by the
pituitary gland and to a lesser extent by numerous extrapituitary tissues. This hormone
affects a great amount of physiological processes [1]. Numerous biological
functions have been attributed to this hormone's ...
Translation_Insulin regulation of translation [score: 1 (0%)]
Insulin plays an important role in the overall regulation
of protein synthesis. Protein synthesis (mRNA translation) is conventionally divided into
three stages: initiation, elongation and termination. Both initiation and elongation can
be controlled by Insulin.
Insulin ...
Transcription_Androgen Receptor nuclear signaling [score: 1 (0%)]
Androgen is the active metabolic product,
5alpha-Dihydrotestosterone, which is produced from the
transformation of Testosterone catalyzed by the
Steroid-5-alpha-reductase, alpha polypeptides 1 and 2 (S5AR1
and S5AR2) [1], [2]. ...
Development_Ligand-independent activation of ESR1 and ESR2 [score: 1 (0%)]
In addition to the conventional hormone-dependent regulation of activity of Estrogen
receptor alpha and beta (ESR1(nuclear) and
ESR2 respectively), there is a cross-talk between signal transduction
pathways and estrogen receptors [1]. Epidermal growth factor
(EGF), ...
Development_Growth hormone signaling via PI3K/AKT and MAPK cascades [score: 1 (0%)]
Growth hormone (GH or Somatotropin) is a major
growth-promoting and metabolic regulatory hormone. Interaction of
Somatotropin with Growth hormone receptor
(GHR), by virtue of receptor dimerization, causes activation
of GHR associated cytoplasmic tyrosine kinase, Janus kinase ...
Development_Activation of ERK by Alpha-1 adrenergic receptors [score: 1 (0%)]
Subtype alpha-1 adrenergic receptors consists of Alpha-1A adrenergic
receptor, Alpha-1B adrenergic receptor and
Alpha-1D adrenergic receptor. They participate in many
physiological processes via different pathways. One of the best studied alpha-1
adrenergic receptors-stimulated ...
Selected targets of Androgen and Estrogen receptors [score: 1 (0%)]
Androgen and Estrogen receptors (Androgen receptor and
ESR1 (nuclear)) function as steroid-hormone activated
transcription factors. Upon binding the hormone ligand, receptors dissociate from
accessory proteins, translocate into the nucleus, dimerize, and then stimulate
transcription ...
Selected targets of SP1 [score: 1 (0%)]
Sp1 transcription factor (SP1) is a transcription factor
involved in gene expression in the early development of an organism. It belongs to the
Sp/KLF family of transcription factors. The SP1
transcription factor contains a zinc finger protein motif, by which it binds directly to
DNA ...
Selected targets of c-Myc [score: 1 (0%)]
V-myc myelocytomatosis viral oncogene homolog (c-Myc) is
a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression,
apoptosis and cellular transformation. c-Myc controls the
transcription of a variety of different targets and regulates different processes, ...
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