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G-protein signaling_Ras family GTPases in kinase cascades (scheme) [score: 1 (0%)]
GTPases of the Ras superfamily are activated upon growth factors stimuli and controls
a wide range of essential biochemical pathways in all eukaryotic cells. One of the most
important functions of Ras proteins is activation of mitogen activated protein kinases
(MAPK). MAPK pathways are important ...
G-protein signaling_Regulation of RAC1 activity [score: 1 (0%)]
Ras-related C3 botulinum toxin substrate 1 (Rac1) belongs
to the Rho subgroup of a family of small GTP-binding proteins (G-proteins) called
monomeric G-proteins. Proteins belonging to the Rho subgroup are involved in cytoskeletal
control, regulation of the formation of the stress fibers, focal ...
G-protein signaling_N-RAS regulation pathway [score: 1 (0%)]
Neuroblastoma RAS viral (v-ras) oncogene homolog (N-RAS)
belongs to Ras family of small GTPases. It serves as a signal transducer from growth
factor receptors and activates numerous effector molecules resulting in cell growth,
differentiation and survival [1], [
Transcription_CREB pathway [score: 1 (0%)]
Extracellular stimuli elicit changes in gene expression in target cells by activating
intracellular protein kinase cascades that phosphorylate transcription factors within the
nucleus. One of the best characterized stimulus-induced transcription factors is cyclic
AMP (cAMP) responsive element binding ...
Development_FGFR signaling pathway [score: 1 (0%)]
Fibroblast growth factor 2 (FGF2) has been implicated in
diverse cellular processes, including apoptosis, cell survival, chemotaxis, cell
adhesion, migration, differentiation, and proliferation [1].
FGF2 induces biological responses by binding to ...
Development_VEGF-family signaling [score: 1 (0%)]
The vascular endothelial growth factor (VEGF) family of ligands and receptors is
crucial for vascular development and neovascularization in physiological and pathological
processes in both embryos, and in adults [1].
VEGFs belong to a family of homodimeric glycoproteins ...
Cytoskeleton remodeling_FAK signaling [score: 1 (0%)]
The biological importance of PTK2 protein tyrosine kinase 2, or Focal
adhesion kinase 1 (FAK1)-mediated signal transduction is
underscored by the fact that this tyrosine kinase plays a fundamental role in embryonic
development, in control of cell migration, cell cycle progression, and in apoptosis.
Binding ...
Cell adhesion_Integrin-mediated cell adhesion and migration [score: 1 (0%)]
Cell migration is a coordinated process that involves rapid changes in the dynamics of
actin filaments, together with the formation and disassembly of cell adhesion sites.
External stimuli that control cell migration are transduced into intracellular
biochemical signals through the interactions of ...
Development_G-Proteins mediated regulation MAPK-ERK signaling [score: 1 (0%)]
Guanine nucleotide binding protein
(G-proteins) are heterotrimeric signaling molecules composed
of three subunits, alpha, beta, and gamma, which dissociate receptor-induced exchange on
the alpha subunit and beta/gamma heterodimer subunit. The G-protein-coupled receptors
(GPCRs) initiate diverse ...
Development_TGF-beta receptor signaling [score: 1 (0%)]
Transforming growth factor beta (TGF-beta) signaling
controls diverse cellular processes, including cell proliferation, differentiation,
adhesion and migration [1], [2], [3].
TGF-beta 1 initiates ...
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