Results

Neuroblastoma RAS viral (v-ras) oncogene homolog (N-RAS) belongs to Ras family of small GTPases. It serves as a signal transducer from growth factor receptors and activates numerous effector molecules resulting in cell growth, differentiation and survival [1], [

Transcription_CREB pathway [score: 1 (0%)]

Extracellular stimuli elicit changes in gene expression in target cells by activating intracellular protein kinase cascades that phosphorylate transcription factors within the nucleus. One of the best characterized stimulus-induced transcription factors is cyclic AMP (cAMP) responsive element binding ...

Development_Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis [score: 1 (0%)]

There are two families of transcription factors that play pivotal roles during mammalian skeletal muscle differentiation. One of them includes MyoD family proteins (also called myogenic regulatory factors or MRFs), with four members Myf5, Myogenic differentiation 1 (MYOD), Myogenin (MYOG), ...

Signal transduction_Erk Interactions: Inhibition of Erk [score: 1 (0%)]

Mitogen-activated protein kinase (MAPK) pathways regulate a variety of physiological processes, such as cell growth, differentiation, and apoptotic cell death. To date, three MAPK pathways have been characterized in detail. The extracellular regulated kinase (ERK) pathway is activated by a large ...

Cytoskeleton remodeling_FAK signaling [score: 1 (0%)]

The biological importance of PTK2 protein tyrosine kinase 2, or Focal adhesion kinase 1 (FAK1)-mediated signal transduction is underscored by the fact that this tyrosine kinase plays a fundamental role in embryonic development, in control of cell migration, cell cycle progression, and in apoptosis.

Binding ...

Signal transduction_Activation of PKC via G-Protein coupled receptor [score: 1 (0%)]

The family of Protein kinase C (PKC) contains 3 functional protein types, 'conventional' PKC-alpha, PKC-beta, and PKC-gamma that are activated by calcium and Diacylglycerol (DAG), 'novel' PKC-delta, PKC-epsilon, PKC-eta, and PKC-theta ...

Development_G-Proteins mediated regulation MAPK-ERK signaling [score: 1 (0%)]

Guanine nucleotide binding protein (G-proteins) are heterotrimeric signaling molecules composed of three subunits, alpha, beta, and gamma, which dissociate receptor-induced exchange on the alpha subunit and beta/gamma heterodimer subunit. The G-protein-coupled receptors (GPCRs) initiate diverse ...

Cytoskeleton remodeling_Reverse signaling by ephrin B [score: 1 (0%)]

Ephrin receptors and Ephrins are both membrane bound, and following their interaction and clustering, each can transduce signals that regulate cell responses [1].

Ephrin receptors activate reverse signaling through their Ephrin ligands ...

Development_VEGF signaling via VEGFR2 - generic cascades [score: 1 (0%)]

VEGF family of ligands and receptors is crucial for vascular development and neovascularization in physiological and pathological processes in both embryo and adult. VEGFR-2 is a high-affinity receptor for VEGF-A. Activated VEGFR-2 can activate p38 MAPK, PI3K reg class IA/ ...

Cytoskeleton remodeling_Role of PKA in cytoskeleton reorganisation [score: 1 (0%)]

A wide variety of soluble signaling mediators utilize the Protein kinase cAMP-dependent (PKA) pathway to regulate cellular processes including intermediary metabolism, ion channel conductivity, and transcription. PKA plays a central role in cytoskeletal regulation and cell migration. ...

Result pages: 1 2 3 Next

RSS	© Copyright 2013 Covance Inc. All rights reserved.