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Regulatory Processes
Diseases
Protein Regulatory Pathways
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Signal transduction_PKA signaling [score: 1 (0%)]
Protein kinase cAMP-dependent (PKA) is an enzyme playing
key role in a number of cellular processes. In its inactivated state,
PKA exists as a tetrameric complex of two catalytic subunits
(PKA-cat alpha and PKA-cat
beta) and two regulatory subunits (PKA-reg) (alpha ...
Signal transduction_PTEN pathway [score: 1 (0%)]
Phosphatase and tensin homolog (PTEN) is a known tumor
suppressor. It inhibits growth factor-induced cell proliferation, division and regulates
Integrin-mediated cell adhesion and survival [1].
PTEN antagonizes Phosphoinositide-3-kinase
(PI3K), ...
Cell adhesion_PLAU signaling [score: 1 (0%)]
The binding of Plasminogen activator, urokinase (PLAU
(UPA)) to its glycosyl-phosphatidyl-inositol (GPI) anchored Plasminogen
activator, urokinase receptor (PLAUR (UPAR) (uPAR)) mediates
a variety of functions including vascular homeostasis, inflammation and tissue repair
[1].
PLAU ...
Development_EGFR signaling via PIP3 [score: 1 (0%)]
The Epidermal growth factor receptor (EGFR) belongs to
the ERBB family of receptor tyrosine kinases, which consists of four closely related
members: EGFR and v-erb-b2 erythroblastic leukemia viral
oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
(ERBB2), ERBB3 ...
Development_EGFR signaling via small GTPases [score: 1 (0%)]
The Epidermal growth factor receptor (EGFR) belongs to
the ERBB family of receptor tyrosine kinases, which consists of four closely related
members: EGFR and v-erb-b2 erythroblastic leukemia viral
oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
(ERBB2), ERBB3 ...
Cell adhesion_Integrin inside-out signaling [score: 1 (0%)]
The integrin family of transmembrane adhesion receptors mediates both cell-cell and
cell- extracellular matrix (ECM) adhesion. One important, rapid and reversible mechanism
for regulating adhesion is increasing the affinity of integrin receptors for their
extracellular ligands (integrin activation). ...
Cell cycle_Spindle assembly and chromosome separation [score: 1 (0%)]
The two critical steps for cell reproduction are to duplicate the contents of
chromosomes and to segregate them into two daughter cells. The linkage between duplicated
chromosomes is established during the S phase (cohesion), persists during their dramatic
structural changes in prometaphase (condensation), ...
Cell adhesion_ECM remodeling [score: 1 (0%)]
Extracellular matrix (ECM) remodeling is involved in normal physiological processes,
such as embryonic development, reproduction, proliferation, cell motility and adhesion,
wound healing, angiogenesis, as well as in disease processes, such as arthritis and
metastasis. Matrix metalloproteinases (MMPs) ...
Apoptosis and survival_Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway [score: 1 (0%)]
The members of the tumour necrosis factor ligand family (TNFs) may induce both
apoptotic and anti-apoptotic pathways. TNFs transduces cellular responses through
activation of different TNF-receptors (TNFRs).
One important mechanism of cell survival is the activation of transcription of
different ...
Apoptosis and survival_Anti-apoptotic TNFs/NF-kB/IAP pathway [score: 1 (0%)]
Members of the tumour necrosis factor ligand family (TNFs) may induce both apoptotic
and anti-apoptotic pathways. TNFs transduces cellular responses through activation of
different TNF-receptors (TNFRs).
One important mechanism of cell survival is activation of transcription of different
anti-apoptotic ...
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