Results
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Cytoskeleton remodeling_Regulation of actin cytoskeleton by Rho GTPases [score: 1 (0%)]
Ras homolog gene family, member A (RhoA) downstream
effector Rho-associated, coiled-coil containing protein kinase
(ROCK) directly phosphorylates LIM domain kinases 1 and 2
(LIMK1 and LIMK2) that in turn
phosphorylates Cofilin. Cofilin
exhibits Actin-depolymerizing ...
Signal transduction_AKT signaling [score: 1 (0%)]
RAC-alpha serine/threonine kinases (AKTs) are crucial
mediators of various cellular process, such as apoptosis, regulation of cell cycle,
protein synthesis and regulation of metabolism. The activity of
AKT is modulated by various proteins, including
Phosphatidylinositol-3-kinase (PI3K),
Phosphoinositide-dependent ...
Signal transduction_IP3 signaling [score: 1 (0%)]
Efficient and coordinated synthesis of the second messengers, including
Inositol-1,4,5-trisphosphate (IP3), Diacylglycerol
(DAG), and
Phosphatidylinositol-3,4,5-trisphosphate (PI(3,4,5)P3), is
necessary for normal cell functioning. Production of secondary messengers is regulated ...
Chemotaxis_CXCR4 signaling pathway [score: 1 (0%)]
Chemokine (C-X-C motif) receptor-4 (CXCR4) is a G
protein-coupled receptor (GPCR). It is the only known receptor for stromal-derived
factor-1 (SDF-1), and SDF-1 is
the only known ligand for CXCR4 [1].
The CXCR4 is expressed in ...
Development_Thrombopoietin-regulated cell processes [score: 1 (0%)]
Thrombopoietin is a hormone involved in biological
effects on a broad spectrum of hematopoietic progenitor cells, including stem cells. It
supports stem cell survival and expansion. It is primarily a key physiological regulator
of steady-state megakaryocytopoiesis, the process of megakaryocyte ...
Cell adhesion_Plasmin signaling [score: 1 (0%)]
Plasmin is a major fibrinolytic protease
with wide substrate specificity.
Plasminogen, a circulating plasma zymogen,
can be converted to Plasmin by tissue-type Plasminogen
activator (PLAT), Plasminogen activator urokinase
(PLAU), Coagulation factor XII,
or ...
Development_A2A receptor signaling [score: 1 (0%)]
Adenosine is a potent biological mediator
that affects numerous cell types, including neuronal cells, platelets, neutrophils and
smooth muscle cells. Currently, four adenosine receptor subtypes have been identified:
A1, A2A, A2B and A3. Adenosine receptors belong to the G-protein-coupled receptor ...
Development_A3 receptor signaling [score: 1 (0%)]
Adenosine is a potent biological mediator
that affects numerous cell types including neural cells, platelets, neutrophils and
smooth muscle cells. Currently, four adenosine receptor subtypes have been identified:
A1, A2A, A2B and A3. Adenosine receptors are G-protein-coupled receptors that ...
Apoptosis and survival_BAD phosphorylation [score: 1 (0%)]
BAD is a member of the BCL-2 family. BCL-2 family members
are regulators of the programmed cell death pathways.
BAD induces apoptosis by inhibiting antiapoptotic
BCL-2-family members - BCL-x,
Bcl-2, thereby allowing two other pro-apoptotic proteins,
BAK ...
Cytoskeleton remodeling_Integrin outside-in signaling [score: 1 (0%)]
Integrins are heterodimeric adhesion receptors composed
of alpha- and beta-subunits. It is known that at least 18 distinct alpha subunits and 8
or more beta subunits lead to generation of 24 alpha/beta heterodimeric receptors. Most
integrins recognize extracellular matrix (ECM) proteins, such ...
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