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Regulatory Processes
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Protein Regulatory Pathways
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G-protein signaling_G-Protein alpha-12 signaling pathway [score: 1 (0%)]
Activation by ligands of G-protein coupled
receptors that interact with the trimeric G-protein alpha-12/beta/gamma
causes the exchange of GDP for GTP bound to G protein alpha subunits followed by
dissociation of the beta/gamma heterodimers. Free alpha and beta/gamma subunits are
active and ...
Development_G-Proteins mediated regulation MAPK-ERK signaling [score: 1 (0%)]
Guanine nucleotide binding protein
(G-proteins) are heterotrimeric signaling molecules composed
of three subunits, alpha, beta, and gamma, which dissociate receptor-induced exchange on
the alpha subunit and beta/gamma heterodimer subunit. The G-protein-coupled receptors
(GPCRs) initiate diverse ...
Cell cycle_Regulation of G1/S transition (part 2) [score: 1 (0%)]
The commencement of the cell cycle coincides with the production and the stabilization
of the Cyclin D. The D-type cyclins are essential for
synchronization of the cell cycle machinery with extracellular signals. [1]
Expression and stability of Cyclin D is ...
Development_TGF-beta receptor signaling [score: 1 (0%)]
Transforming growth factor beta (TGF-beta) signaling
controls diverse cellular processes, including cell proliferation, differentiation,
adhesion and migration [1], [2], [3].
TGF-beta 1 initiates ...
Development_A2B receptor: action via G-protein alpha s [score: 1 (0%)]
Adenosine A2B
receptor influences cell differentiation and proliferation.
A2B receptors are G-protein-coupled receptors coupling to
classical second messenger pathways, such as modulation of Cyclic Adenosine
3',5'-phosphate (cAMP)
production or the Phospholipase ...
Translation _Regulation of EIF4F activity [score: 1 (0%)]
Protein biosynthesis is largely governed by a cohort of Eukaryotic translation
initiation factors (eIF) that mediate specific steps in the
initiation process. A rate-limiting step in translation
initiation involves formation of the eIF4F complex that
recruits ...
Translation _Regulation of EIF2 activity [score: 1 (0%)]
Eukaryotic translation initiation factors (eIF2) is a
G-protein that is composed of 3 non-identical subunits,
eIF2S1, eIF2S2
and eIF2S3, and catalyzes the first regulated
step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S
ribosomal ...
Development_Notch Signaling Pathway [score: 1 (0%)]
Notch homolog 1 translocation-associated (NOTCH1) is
synthesized as NOTCH1 precursor, which is cleaved by
Furin to NOTCH1
receptor form. NOTCH1 receptor
is activated by Jagged [1]. O-fucosylpeptide
3-beta-N-acetylglucosaminyltransferase ...
Signal transduction_JNK pathway [score: 1 (0%)]
The Mitogen-activated protein kinases 8-10
(JNK(MAPK8-10)) belong to a sub-group of evolutionarily
conserved mitogen-activated protein kinases (MAPK) activated primarily by cytokines,
growth factors and by exposure to environmental stress. JNK(MAPK8-10)
activity is regulated through ...
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