Multicellular organisms are separated from external environment by a layer of epithelial cells whose integrity is maintained by intercellular junction complexes composed of tight junctions (TJ), adherens junctions, and desmosomes. Tight cell junctions serve as a physical barrier to prevent solutes ...

The cytoskeleton in most eukaryotic cells consists of three distinct, yet interconnected, filament systems: Actin filaments, Microtubules and intermediate filaments. Cell assembly is integrated by the network of intermediate filaments (IFs) and by their interactions with other cytoskeleton ...