Extracellular matrix (ECM) remodeling is involved in normal physiological processes, such as embryonic development, reproduction, proliferation, cell motility and adhesion, wound healing, angiogenesis, as well as in disease processes, such as arthritis and metastasis. Matrix metalloproteinases (MMPs) ...

Contacts between endothelial cells are of great importance for blood vessel formation. The formation and maintenance of endothelial cell contacts require the complex interplay of plasma membrane proteins, cytoskeleton components, and signaling molecules. Some of these molecules are specifically ...

Extracellular matrix (ECM) is composed of several macromolecules bound together in a complex network. This structure allows cells to adhere, migrate and interact. Hyaluronic acid, a glycosaminoglycan, is a major component of ECM. Hyaluronic acid-binding proteins such as hyaluronic acid ...

The family ...

Multicellular organisms are separated from external environment by a layer of epithelial cells whose integrity is maintained by intercellular junction complexes composed of tight junctions (TJ), adherens junctions, and desmosomes. Tight cell junctions serve as a physical barrier to prevent solutes ...

CDK5 is abundantly expressed in the adult brain. Moreover, it is present in subcellular fractions enriched for synaptic membranes, and localize to pre- and postsynaptic ...

Transport vesicles are classified according to the components of the protein coat that surrounds them during their genesis and early life cycle of endocytosis. One of the most common and probably best-characterized classes ...

The cytoskeleton in most eukaryotic cells consists of three distinct, yet interconnected, filament systems: Actin filaments, Microtubules and intermediate filaments. Cell assembly is integrated by the network of intermediate filaments (IFs) and by their interactions with other cytoskeleton ...