DNA damage-dependent activation of the breast and ovarian cancer susceptibility protein 1 (Brca1) occurs via activation of ataxia telangiectasia mutated serine-protein kinase (ATM) [1] or ataxia telangiectasia and Rad3 related protein kinase (ATR) ...

The two critical steps for cell reproduction are to duplicate the contents of chromosomes and to segregate them into two daughter cells. The linkage between duplicated chromosomes is established during the S phase (cohesion), persists during their dramatic structural changes in prometaphase (condensation), ...