Apoptosis is an evolutionarily conserved type of programmed cell death essential for
development, homeostasis, and self-defense against infection. It can be triggered by a
number of factors including UV- or gamma-irradiation, chemotherapeutic ...
Caspases are the central components of the apoptotic response. The apoptotic caspases
are generally divided into two classes: the initiator caspases, which include
-9 and -10 and the effector
caspases, which include ...
Death receptors such as FasR belong to a Tumour Necrosis Factor (TNF) superfamily of
receptors involved in proliferation, differentiation and apoptosis.
FasR is ubiquitously expressed in various tissues, but its
ligand FasL is expressed mainly in ...
The tumor necrosis factor (TNF-alpha) is a potent cytokine produced by many cell types, including macrophages, monocytes, lymphocytes, keratinocytes and fibroblasts, in response to inflammation, infection, injury and other environmental challenges. ...
Members of the tumour necrosis factor ligand family (TNFs) induce both apoptotic and
anti-apoptotic pathways. TNFs transduce cellular responses through activation of
different TNF-receptors (TNFRs) , [