Regulation of Apoptosis by Mitochondrial Proteins
Apoptosis is an evolutionarily conserved type of programmed cell death
essential for development, homeostasis, and self-defense against
infection. It can ...
Caspases are the central components of the apoptotic response. The
apoptotic caspases are generally divided into two classes: the initiator
caspases, which include ...
FAS signaling cascade
Death receptors such as FasR belong to a Tumour Necrosis Factor (TNF)
superfamily of receptors involved in proliferation, differentiation and
apoptosis. FasR is ubiquitously ...
The tumor necrosis factor (TNF-alpha) is a potent cytokine
produced by many cell types, including macrophages, monocytes,
lymphocytes, keratinocytes and fibroblasts, in response ...
Apoptotic TNF-family pathways
Members of the tumour necrosis factor ligand family (TNFs) induce both
apoptotic and anti-apoptotic pathways. TNFs transduce cellular ...