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Regulatory Processes
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Translation _Regulation of EIF4F activity [score: 1 (0%)]

Protein biosynthesis is largely governed by a cohort of Eukaryotic translation initiation factors (eIF) that mediate specific steps in the initiation process. A rate-limiting step in translation initiation involves formation of the eIF4F complex that recruits ...

Translation _Regulation of EIF2 activity [score: 1 (0%)]

Eukaryotic translation initiation factors (eIF2) is a G-protein that is composed of 3 non-identical subunits, eIF2S1, eIF2S2 and eIF2S3, and catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal ...

Signal transduction_PTEN pathway [score: 1 (0%)]

Phosphatase and tensin homolog (PTEN) is a known tumor suppressor. It inhibits growth factor-induced cell proliferation, division and regulates Integrin-mediated cell adhesion and survival [1].

PTEN antagonizes Phosphoinositide-3-kinase (PI3K), ...

Translation_Insulin regulation of translation [score: 1 (0%)]

Insulin plays an important role in the overall regulation of protein synthesis. Protein synthesis (mRNA translation) is conventionally divided into three stages: initiation, elongation and termination. Both initiation and elongation can be controlled by Insulin.

Insulin ...

Regulation of lipid metabolism_Insulin signaling:generic cascades [score: 1 (0%)]

The binding of Insulin to the extracellular domain of the Insulin receptor results in the activation of the tyrosine kinase activity of the receptor. Following the autophosphorylation, the Insulin receptor phosphorylates a number of intracellular substrates to initiate a series ...

Translation_Non-genomic (rapid) action of Androgen Receptor [score: 1 (0%)]

Androgen is the active metabolic product, 5alpha-Dihydrotestosterone (DHT), which is produced from the transformation of Testosterone catalyzed by the Steroid-5-alpha-reductase, alpha polypeptides 1 and 2 (S5AR1 and S5AR2) [1], [2]. ...

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