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Protein Regulatory Pathways
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G-protein signaling_N-RAS regulation pathway [score: 1 (0%)]
Neuroblastoma RAS viral (v-ras) oncogene homolog (N-RAS)
belongs to Ras family of small GTPases. It serves as a signal transducer from growth
factor receptors and activates numerous effector molecules resulting in cell growth,
differentiation and survival [1], [
Transcription_CREB pathway [score: 1 (0%)]
Extracellular stimuli elicit changes in gene expression in target cells by activating
intracellular protein kinase cascades that phosphorylate transcription factors within the
nucleus. One of the best characterized stimulus-induced transcription factors is cyclic
AMP (cAMP) responsive element binding ...
Immune response_T cell receptor signaling pathway [score: 1 (0%)]
T cell receptors (TCR) play a key role in functioning of
T cells and formation of the immunological synapse. It provides connection between T cell
and the antigen-presenting cell (APC) [1]. TCRs are composed of
ligand-binding subunits, the alpha and beta chains, ...
Cytoskeleton remodeling_FAK signaling [score: 1 (0%)]
The biological importance of PTK2 protein tyrosine kinase 2, or Focal
adhesion kinase 1 (FAK1)-mediated signal transduction is
underscored by the fact that this tyrosine kinase plays a fundamental role in embryonic
development, in control of cell migration, cell cycle progression, and in apoptosis.
Binding ...
Development_G-Proteins mediated regulation MAPK-ERK signaling [score: 1 (0%)]
Guanine nucleotide binding protein
(G-proteins) are heterotrimeric signaling molecules composed
of three subunits, alpha, beta, and gamma, which dissociate receptor-induced exchange on
the alpha subunit and beta/gamma heterodimer subunit. The G-protein-coupled receptors
(GPCRs) initiate diverse ...
Cytoskeleton remodeling_Reverse signaling by ephrin B [score: 1 (0%)]
Ephrin receptors and Ephrins
are both membrane bound, and following their interaction and clustering, each can
transduce signals that regulate cell responses [1].
Ephrin receptors activate reverse signaling through their
Ephrin ligands ...
Cytoskeleton remodeling_Role of PKA in cytoskeleton reorganisation [score: 1 (0%)]
A wide variety of soluble signaling mediators utilize the Protein
kinase cAMP-dependent (PKA) pathway to regulate cellular
processes including intermediary metabolism, ion channel conductivity, and transcription.
PKA plays a central role in cytoskeletal regulation and cell
migration. ...
Signal transduction_IP3 signaling [score: 1 (0%)]
Efficient and coordinated synthesis of the second messengers, including
Inositol-1,4,5-trisphosphate (IP3), Diacylglycerol
(DAG), and
Phosphatidylinositol-3,4,5-trisphosphate (PI(3,4,5)P3), is
necessary for normal cell functioning. Production of secondary messengers is regulated ...
Development_A3 receptor signaling [score: 1 (0%)]
Adenosine is a potent biological mediator
that affects numerous cell types including neural cells, platelets, neutrophils and
smooth muscle cells. Currently, four adenosine receptor subtypes have been identified:
A1, A2A, A2B and A3. Adenosine receptors are G-protein-coupled receptors that ...
Immune response _CCR3 signaling in eosinophils [score: 1 (0%)]
Human eosinophils are key effector cells implicated in a number of chronic
inflammatory reactions, associated with bronchial asthma, allergic-inflammatory diseases
and parasitic infections. Chemoattractants/chemokines, generated at the affected sites,
promote migration of eosinophils from vasculature ...
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