GTPases of the Ras superfamily are activated upon growth factors stimuli and controls
a wide range of essential biochemical pathways in all eukaryotic cells. One of the most
important functions of Ras proteins is activation of mitogen activated protein kinases
(MAPK). MAPK pathways are important ...
Ras-related C3 botulinum toxin substrate 1 (Rac1) belongs
to the Rho subgroup of a family of small GTP-binding proteins (G-proteins) called
monomeric G-proteins. Proteins belonging to the Rho subgroup are involved in cytoskeletal
control, regulation of the formation of the stress fibers, focal ...
Neuroblastoma RAS viral (v-ras) oncogene homolog (N-RAS)
belongs to Ras family of small GTPases. It serves as a signal transducer from growth
factor receptors and activates numerous effector molecules resulting in cell growth,
differentiation and survival , [
Extracellular stimuli elicit changes in gene expression in target cells by activating
intracellular protein kinase cascades that phosphorylate transcription factors within the
nucleus. One of the best characterized stimulus-induced transcription factors is cyclic
AMP (cAMP) responsive element binding ...
T cell receptors(TCR) play a key role in functioning of
T cells and formation of the immunological synapse. It provides connection between T cell
and the antigen-presenting cell (APC) . TCRs are composed of
ligand-binding subunits, the alpha and beta chains, ...
The vascular endothelial growth factor (VEGF) family of ligands and receptors is
crucial for vascular development and neovascularization in physiological and pathological
processes in both embryos, and in adults .
VEGFs belong to a family of homodimeric glycoproteins ...
The biological importance of PTK2 protein tyrosine kinase 2, or Focal
adhesion kinase 1 (FAK1)-mediated signal transduction is
underscored by the fact that this tyrosine kinase plays a fundamental role in embryonic
development, in control of cell migration, cell cycle progression, and in apoptosis.
Cell migration is a coordinated process that involves rapid changes in the dynamics of
actin filaments, together with the formation and disassembly of cell adhesion sites.
External stimuli that control cell migration are transduced into intracellular
biochemical signals through the interactions of ...