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Apoptosis and survival_Role of CDK5 in neuronal death and survival [score: 1 (0%)]

Cyclin-dependent kinase 5 (CDK5) is a member of the small serine/threonine cyclin-dependent kinase (CDK) family.

The best known role of CDK5 is its regulatoin of the cytoskeleton architecture of the central nervous system (CNS). There is also some evidence that links CDK5 ...

Development_Activation of ERK by Alpha-1 adrenergic receptors [score: 1 (0%)]

Subtype alpha-1 adrenergic receptors consists of Alpha-1A adrenergic receptor, Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor. They participate in many physiological processes via different pathways. One of the best studied alpha-1 adrenergic receptors-stimulated ...

Development_Alpha-2 adrenergic receptor activation of ERK [score: 1 (0%)]

Alpha-2A adrenergic receptor, Alpha-2B adrenergic receptor, and Alpha-2C-1 adrenergic receptor participate in activation of Mitogen-activated protein kinases 1 and 3 (ERK1/2) via different ways [1].

Alpha-2A adrenergic receptor ...

Development_Dopamine D2 receptor transactivation of EGFR [score: 1 (0%)]

Dopamine is a major transmitter and neuromodulator in the CNS. This transmitter mediates its signaling through GPCRs of which the Dopamine D2 receptor class of ...

Development_ACM2 and ACM4 activation of ERK [score: 1 (0%)]

ACM2 and ACM4 act via Guanine nucleotide binding proteins (G-protein) of G-protein alpha-i family. ACM2 can activate ...

Mucin expression in CF via TLRs, EGFR signaling pathways [score: 1 (0%)]

Cystic Fibrosis (CF) is a potentially lethal genetic disease that typically results in the development of bronchial inflammation, bronchiectasis, the progressive loss of lung function and ultimately death [1].

CF was initially called "mucoviscidosis" because of ...

Inhibitory action of Lipoxins on neutrophil migration [score: 1 (0%)]

Deregulated neutrophilic inflammation and chronic infection lead to progressive destruction of the airways in cystic fibrosis (CF). In normal tissues, lipoxins are endogenous anti-inflammatory lipid mediators in regulation of neutrophilic inflammation [1]. In CF, production ...

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