Results
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Development_Prolactin receptor signaling [score: 1 (0%)]
Prolactin is a polypeptide hormone secreted by the
pituitary gland and to a lesser extent by numerous extrapituitary tissues. This hormone
affects a great amount of physiological processes [1]. Numerous biological
functions have been attributed to this hormone's ...
Transcription_PPAR Pathway [score: 1 (0%)]
Peroxisome Proliferator-Activated Receptors (PPAR) are
ligand-inducible transcription factors that belong to the nuclear hormone receptor
superfamily. The PPAR group consists of three types:
PPAR-alpha, PPAR-beta(delta)
and PPAR-gamma. They have some differences ...
Cytoskeleton remodeling_Regulation of actin cytoskeleton by Rho GTPases [score: 1 (0%)]
Ras homolog gene family, member A (RhoA) downstream
effector Rho-associated, coiled-coil containing protein kinase
(ROCK) directly phosphorylates LIM domain kinases 1 and 2
(LIMK1 and LIMK2) that in turn
phosphorylates Cofilin. Cofilin
exhibits Actin-depolymerizing ...
Signal transduction_IP3 signaling [score: 1 (0%)]
Efficient and coordinated synthesis of the second messengers, including
Inositol-1,4,5-trisphosphate (IP3), Diacylglycerol
(DAG), and
Phosphatidylinositol-3,4,5-trisphosphate (PI(3,4,5)P3), is
necessary for normal cell functioning. Production of secondary messengers is regulated ...
Chemotaxis_CXCR4 signaling pathway [score: 1 (0%)]
Chemokine (C-X-C motif) receptor-4 (CXCR4) is a G
protein-coupled receptor (GPCR). It is the only known receptor for stromal-derived
factor-1 (SDF-1), and SDF-1 is
the only known ligand for CXCR4 [1].
The CXCR4 is expressed in ...
Development_Neurotrophin family signaling [score: 1 (0%)]
Factors of the neurotrophin family (NGF,
BDNF and neurotrophins NT-3 and
NT-4/5), promote neuronal survival or death. The best
characterized receptors for these trophic factors are the tropomyosin-related tyrosine
kinase receptors TrkA, TrkB,
and TrkC, ...
Development_A2A receptor signaling [score: 1 (0%)]
Adenosine is a potent biological mediator
that affects numerous cell types, including neuronal cells, platelets, neutrophils and
smooth muscle cells. Currently, four adenosine receptor subtypes have been identified:
A1, A2A, A2B and A3. Adenosine receptors belong to the G-protein-coupled receptor ...
Development_A3 receptor signaling [score: 1 (0%)]
Adenosine is a potent biological mediator
that affects numerous cell types including neural cells, platelets, neutrophils and
smooth muscle cells. Currently, four adenosine receptor subtypes have been identified:
A1, A2A, A2B and A3. Adenosine receptors are G-protein-coupled receptors that ...
Apoptosis and survival_BAD phosphorylation [score: 1 (0%)]
BAD is a member of the BCL-2 family. BCL-2 family members
are regulators of the programmed cell death pathways.
BAD induces apoptosis by inhibiting antiapoptotic
BCL-2-family members - BCL-x,
Bcl-2, thereby allowing two other pro-apoptotic proteins,
BAK ...
Cytoskeleton remodeling_Integrin outside-in signaling [score: 1 (0%)]
Integrins are heterodimeric adhesion receptors composed
of alpha- and beta-subunits. It is known that at least 18 distinct alpha subunits and 8
or more beta subunits lead to generation of 24 alpha/beta heterodimeric receptors. Most
integrins recognize extracellular matrix (ECM) proteins, such ...
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