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Angiotensin II, a major effector peptide of the renin-angiotensin system, is believed to play a critical role in the pathogenesis of cardiovascular remodeling associated with hypertension, heart failure, and atherosclerosis. [1]

Angiotensin ...

Signal transduction_Activation of PKC via G-Protein coupled receptor [score: 1 (0%)]

PKC family signaling

The family of Protein kinase C (PKC) contains 3 functional protein types, "conventional" PKC-alpha, PKC-beta, and PKC-gamma that are activated by calcium and Diacylglycerol (DAG), "novel" PKC-delta, PKC-epsilon, PKC-eta, ...

G-protein signaling_G-Protein alpha-12 signaling pathway [score: 1 (0%)]

G-protein alpha-12 family signaling

Activation by ligands of G-protein coupled receptors that interact with the trimeric G-protein alpha-12/beta/gamma causes the exchange of GDP for GTP bound to G protein alpha subunits followed by dissociation of the beta/gamma heterodimers. ...

Development_G-Proteins mediated regulation MAPK-ERK signaling [score: 1 (0%)]

G-protein-mediated regulation of MAPK-ERK signaling

Guanine nucleotide binding protein (G-proteins) are heterotrimeric signaling molecules composed of three subunits, alpha, beta, and gamma, which ...

Development_A2B receptor: action via G-protein alpha s [score: 1 (0%)]

Adenosine A2B receptor signaling

Adenosine A2B receptor influences cell differentiation and proliferation. A2B receptors are G-protein-coupled receptors coupling to classical second ...

Development_Angiotensin signaling via beta-Arrestin [score: 1 (0%)]

Angiotensin signaling via Beta-arrestin

Angiotensin II, a major effector peptide of the renin-angiotensin system, is now believed to play a critical role in the pathogenesis of cardiovascular remodeling associated with hypertension, heart failure, and atherosclerosis [1].

Angiotensin ...

Chemotaxis_CXCR4 signaling pathway [score: 1 (0%)]

CXCR4 signaling via small GTPases

Chemokine (C-X-C motif) receptor-4 (CXCR4) is a G protein-coupled receptor (GPCR). It is the only known receptor for stromal-derived factor-1 (SDF-1), and SDF-1 is the only known ligand for CXCR4 [1].

The ...

Development_A2A receptor signaling [score: 1 (0%)]

Adenosine A2A receptor signaling

Adenosine is a potent biological mediator that affects numerous cell types, including neuronal cells, platelets, neutrophils and smooth muscle cells. Currently, four ...

Development_A3 receptor signaling [score: 1 (0%)]

Adenosine A3 receptor signaling

Adenosine is a potent biological mediator that affects numerous cell types including neural cells, platelets, neutrophils and smooth muscle cells. Currently, four adenosine ...

Signal transduction_PKA signaling [score: 1 (0%)]

PKA signaling

Protein kinase cAMP-dependent (PKA) is an enzyme playing key role in a number of cellular processes. In its inactivated state, PKA exists as a tetrameric complex of two catalytic ...

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