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Human eosinophils are key effector cells implicated in a number of chronic inflammatory reactions, associated with bronchial asthma, allergic-inflammatory diseases and parasitic infections. Chemoattractants/chemokines, generated at the affected sites, promote migration of eosinophils from vasculature ...

Development_Endothelin-1/EDNRA transactivation of EGFR [score: 1 (0%)]

Endothelin-1, a potent endothelium-derived vasoconstrictor peptide, exerts a growth-promoting effect on vascular smooth muscle cells, implicating its pathogenic role in vascular remodeling. Endothelin-1 action is initiated by its binding to Endothelin receptor type A (EDNRA) ...

Development_Endothelin-1/EDNRA signaling [score: 1 (0%)]

Endothelin-1, a potent endothelium-derived vasoconstrictor peptide, exerts a growth-promoting effect on vascular smooth muscle cells, implicating its pathogenic role in vascular remodeling. Endothelin-1 action is exerted by its binding to Endothelin receptor type A (EDNRA) [

Development_EDNRB signaling [score: 1 (0%)]

Endothelin receptor type B (EDNRB) belongs to the guanine nucleotide binding protein (G-protein) coupled receptor family. Endothelin-1 is most investigated physiological ligand of EDNRB [1]. EDNRB binds to many types of the G-proteins but the ...

Development_Activation of ERK by Alpha-1 adrenergic receptors [score: 1 (0%)]

Subtype alpha-1 adrenergic receptors consists of Alpha-1A adrenergic receptor, Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor. They participate in many physiological processes via different pathways. One of the best studied alpha-1 adrenergic receptors-stimulated ...

Neurophysiological process_Glutamate regulation of Dopamine D1A receptor signaling [score: 1 (0%)]

Glutamic acid is the major excitatory neurotransmitter in the brain. The excitation of medium spiny neurons is regulated by a balance of glutamatergic inputs from corticostriatal and thalamostriatal pathways and dopaminergic inputs from the nigrostriatal pathway [1].

Dopamine ...

Development_Alpha-2 adrenergic receptor activation of ERK [score: 1 (0%)]

Alpha-2A adrenergic receptor, Alpha-2B adrenergic receptor, and Alpha-2C-1 adrenergic receptor participate in activation of Mitogen-activated protein kinases 1 and 3 (ERK1/2) via different ways [1].

Alpha-2A adrenergic receptor ...

Development_Beta-adrenergic receptors signaling via cAMP [score: 1 (0%)]

Beta-1 adrenergic receptor, Beta-2 adrenergic receptor and Beta-3 adrenergic receptor are ...

Development_Dopamine D2 receptor transactivation of EGFR [score: 1 (0%)]

Dopamine is a major transmitter and neuromodulator in the CNS. This transmitter mediates its signaling through GPCRs of which the Dopamine D2 receptor class of ...

Development_ACM2 and ACM4 activation of ERK [score: 1 (0%)]

ACM2 and ACM4 act via Guanine nucleotide binding proteins (G-protein) of G-protein alpha-i family. ACM2 can activate ...

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