Neuroblastoma RAS viral (v-ras) oncogene homolog (N-RAS)
belongs to Ras family of small GTPases. It serves as a signal transducer from growth
factor receptors and activates numerous effector molecules resulting in cell growth,
differentiation and survival ...
Extracellular stimuli elicit changes in gene expression in target cells by activating intracellular protein kinase cascades that phosphorylate transcription factors within the nucleus. One of the best characterized stimulus-induced transcription factors ...
Angiotensin II, a major effector peptide of the
renin-angiotensin system, is believed to play a critical role in the pathogenesis of
cardiovascular remodeling associated with hypertension, heart failure, and
The biological importance of PTK2 protein tyrosine kinase 2, or Focal adhesion kinase 1 (FAK1)-mediated signal transduction is underscored by the fact that this tyrosine kinase plays a fundamental role in embryonic development, in control of cell migration, ...
The family of Protein kinase C (PKC)
contains 3 functional protein types, "conventional"
PKC-alpha, PKC-beta, and
PKC-gamma that are activated by calcium and Diacylglycerol
(DAG), "novel" PKC-delta,
PKC-epsilon, PKC-eta, ...