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Protein Regulatory Pathways
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G-protein signaling_N-RAS regulation pathway [score: 1 (0%)]
Neuroblastoma RAS viral (v-ras) oncogene homolog (N-RAS)
belongs to Ras family of small GTPases. It serves as a signal transducer from growth
factor receptors and activates numerous effector molecules resulting in cell growth,
differentiation and survival [1], [
Transcription_CREB pathway [score: 1 (0%)]
Extracellular stimuli elicit changes in gene expression in target cells by activating
intracellular protein kinase cascades that phosphorylate transcription factors within the
nucleus. One of the best characterized stimulus-induced transcription factors is cyclic
AMP (cAMP) responsive element binding ...
Immune response _IFN gamma signaling pathway [score: 1 (0%)]
Interferons (IFNs) are pleiotropic cytokines that mediate anti-viral responses,
inhibit proliferation and participate in immune surveillance and tumor suppression by
inducing the transcription of a number of IFN-stimulated genes. The IFN family includes
two main classes of related cytokines, type ...
Immune response_T cell receptor signaling pathway [score: 1 (0%)]
T cell receptors (TCR) play a key role in functioning of
T cells and formation of the immunological synapse. It provides connection between T cell
and the antigen-presenting cell (APC) [1]. TCRs are composed of
ligand-binding subunits, the alpha and beta chains, ...
Development_Angiotensin signaling via PYK2 [score: 1 (0%)]
Angiotensin II, a major effector peptide of the
renin-angiotensin system, is believed to play a critical role in the pathogenesis of
cardiovascular remodeling associated with hypertension, heart failure, and
atherosclerosis. [1]
Angiotensin II receptor, ...
Signal transduction_Erk Interactions: Inhibition of Erk [score: 1 (0%)]
Mitogen-activated protein kinase (MAPK) pathways regulate a variety of physiological
processes, such as cell growth, differentiation, and apoptotic cell death. To date, three
MAPK pathways have been characterized in detail. The extracellular regulated kinase (ERK)
pathway is activated by a large ...
Cytoskeleton remodeling_FAK signaling [score: 1 (0%)]
The biological importance of PTK2 protein tyrosine kinase 2, or Focal
adhesion kinase 1 (FAK1)-mediated signal transduction is
underscored by the fact that this tyrosine kinase plays a fundamental role in embryonic
development, in control of cell migration, cell cycle progression, and in apoptosis.
Binding ...
Development_G-Proteins mediated regulation MAPK-ERK signaling [score: 1 (0%)]
Guanine nucleotide binding protein
(G-proteins) are heterotrimeric signaling molecules composed
of three subunits, alpha, beta, and gamma, which dissociate receptor-induced exchange on
the alpha subunit and beta/gamma heterodimer subunit. The G-protein-coupled receptors
(GPCRs) initiate diverse ...
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