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Cell adhesion_Integrin inside-out signaling [score: 1 (0%)]
The integrin family of transmembrane adhesion receptors mediates both cell-cell and
cell- extracellular matrix (ECM) adhesion. One important, rapid and reversible mechanism
for regulating adhesion is increasing the affinity of integrin receptors for their
extracellular ligands (integrin activation). ...
Immune response _CCR3 signaling in eosinophils [score: 1 (0%)]
Human eosinophils are key effector cells implicated in a number of chronic
inflammatory reactions, associated with bronchial asthma, allergic-inflammatory diseases
and parasitic infections. Chemoattractants/chemokines, generated at the affected sites,
promote migration of eosinophils from vasculature ...
Development_EPO-induced MAPK pathway [score: 1 (0%)]
Erythropoiesis is the main pathway of pluripotent hematopoietic stem cell development
into mature end stage cells. Erythropoietin (Epo) is a major
lineage-specific hematopoietic growth factor required for survival, proliferation and
differentiation of committed erythroid progenitor cells [
Immune response_CD16 signaling in NK cells [score: 1 (0%)]
Natural killer (NK) cells mediate antibody-depend cellular cytotoxicity through the Fc
fragment of IgG, low affinity IIIa and receptor (CD16a) (Fc gamma RIII
alpha (CD16)) [1], [2]. The preferred ligands
for Fc gamma RIII alpha (CD16) ...
Development_Endothelin-1/EDNRA transactivation of EGFR [score: 1 (0%)]
Endothelin-1, a potent endothelium-derived
vasoconstrictor peptide, exerts a growth-promoting effect on vascular smooth muscle
cells, implicating its pathogenic role in vascular remodeling.
Endothelin-1 action is initiated by its binding to
Endothelin receptor type A (EDNRA) ...
Development_Endothelin-1/EDNRA signaling [score: 1 (0%)]
Endothelin-1, a potent endothelium-derived
vasoconstrictor peptide, exerts a growth-promoting effect on vascular smooth muscle
cells, implicating its pathogenic role in vascular remodeling.
Endothelin-1 action is exerted by its binding to Endothelin
receptor type A (EDNRA) [
Development_EDNRB signaling [score: 1 (0%)]
Endothelin receptor type B (EDNRB) belongs to the guanine
nucleotide binding protein (G-protein) coupled receptor family.
Endothelin-1 is most investigated physiological ligand of
EDNRB [1]. EDNRB
binds to many types of the G-proteins but the ...
Neurophysiological process_PGE2-induced pain processing [score: 1 (0%)]
Prostaglandin E2 (PGE2) is a
crucial mediator of inflammatory pain sensitization. Prostaglandin
E2 is produced in response to inflammation both in peripheral inflamed
tissues and in the spinal cord [1].
Activation of the cytosolic phospholipase ...
Development_Activation of ERK by Alpha-1 adrenergic receptors [score: 1 (0%)]
Subtype alpha-1 adrenergic receptors consists of Alpha-1A adrenergic
receptor, Alpha-1B adrenergic receptor and
Alpha-1D adrenergic receptor. They participate in many
physiological processes via different pathways. One of the best studied alpha-1
adrenergic receptors-stimulated ...
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