Androgen is the active metabolic product, 5alpha-Dihydrotestosterone (DHT), which is produced from the transformation of Testosterone catalyzed by the Steroid-5-alpha-reductase, alpha polypeptides 1 and 2 (S5AR1 and S5AR2) [1], [2]. ...

In addition to the conventional hormone-dependent regulation of activity of Estrogen receptor alpha and beta (ESR1(nuclear) and ESR2 respectively), there is a cross-talk between signal transduction pathways and estrogen receptors [1]. Epidermal growth factor (EGF), ...

Estradiol exerts an anti-apoptotic effect on a wide variety of tissues. Estradiol as classical steroid hormone diffuses through plasma membrane, activates ESR1 ...