RE1-silencing transcription factor (NRSF) is a member of the Kruppel-type zinc finger transcription factor family. It is a transcriptional repressor of neuronal genes in non-neuronal tissues. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. NRSF is also found in undifferentiated neuronal progenitor cells and it is thought that this repressor may act as a master negative regular of neurogenesis. NRSF targets regulate a lot of cellular processes such as cytoskeleton remodeling, cell adhesion, proteolysis and others [1], [2].

NRSF may regulate transcription of Tryptase gamma 1 (Tryptase gamma) and thereby modulate proteolysis [3], [4].

Another target of NRSF is Mitogen-activated protein kinase kinase kinase 9 (MLK1(MAP3K9)), which is a regulator of apoptosis [5], [6].

NRSF may also regulate Potassium voltage-gated channel, Shab-related subfamily, member 2 (Kv2.2), which controls potassium transport [7], [8].

Such targets of NRSF like Spectrin, alpha, erythrocytic 1 (SPTA1), Microtubule-associated protein 1B (MAP-1B), Kinesin family member 5B (KIF5B), Kinesin heavy chain member 2A (Kif2a), Carcinoembryonic antigen-related cell adhesion molecules 3, 4, 7, 20 and 21 (CEACAM3, CECAM4, CEACAM7, CEACAM20 and CEACAM21) regulate cytoskeleton remodeling, phagocytosis, microtubule-based movements and cell adhesion [4], [6], [8], [9], [10], [11], [12].

In addition, NRSF can regulate the transcription of Carcinoembryonic antigen-related cell adhesion molecule 8 (CD67), which is a regulator of immune response [8], [13].

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