V-myc myelocytomatosis viral oncogene homolog (c-Myc) is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. c-Myc controls the transcription of a variety of different targets and regulates different processes, such as cell adhesion, DNA replication, inflammation, molecular transport, cell metabolism to name a few [1].

c-Myc activates transcription of Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) regulating cell adhesion [2], [3]. Pericentrin (Kendrin) and TH1-like (TH1L), regulated by c-Myc, promote cell cycle progression and gene transcription [4], [5], [6], [7]. c-Myc may also control DNA replication by activating the transcription of SET nuclear oncogene (SET) [8], [9].

c-Myc target Troponin T type 1 (TNNT1) regulates muscle contraction [10], [11].

c-Myc is an important regulator of enzymes of cell metabolism, including Vitamin K epoxide reductase complex, subunit 1 (VKOR), Mannosidase, alpha, class 2A, member 1 (MA2A1), Fucosyltransferase 4 (FUT4), Lactate dehydrogenase B (LDHB), Lactate dehydrogenase D (LDHD), ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 (SIAT8A) [7], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21].

c-Myc may also modulate proteolysis by regulating Ubiquitin-like modifier activating enzyme 7 (UBE1L) and Hepsin; and RNA processing by regulation of Fibrillarin [9], [11], [22], [23], [24], [25].

In addition, c-Myc regulates many ion and protein transporters, including nucleoporin 153kDa (NUP153), Chloride intracellular channel 4 (CLIC4), LIM and SH3 protein 1 (LASP1) and Golgi integral membrane protein 4 (GPP130) [9], [18], [26], [27], [28], [29], [30], [31].

c-Myc controls inflammatory processes by the regulation of Chemokine (C-C motif) receptor 7 (CCR7) [11], [32].

Finally, c-Myc modulates processes of development by the regulating the transcription of Thyroid stimulating hormone, beta (TSH-beta), Fibroblast growth factor 23 (FGF23) and Msh homeobox 1 (MSX1) [7], [20], [33], [34], [35].

There are also several c-Myc targets with unknown functionality, e.g. non-protein coding RNA 273 (LOC649159) [18].

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