Clinical Pharmacology (Phase I-IIa)
Leeds, England |
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Quick Links to Leeds CRU capabilities
Site Features
Site Capabilities |
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| Site Features |
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The Clinical Research Unit in Leeds has been conducting clinical trials for more than 20 years and has a long history with First-in-Human trials to Proof-of-Concept. This 72-bed facility is strategically located adjacent to the University of Leeds and the renowned Leeds General Infirmary. Collaborations with the Key Opinion Leaders at the Institute of Psychological Sciences at the University enhance the design and conduct of studies with potential anti-obesity compound in the in-house Human Appetite Laboratory facility. Partnerships with the Leeds Dental Institute and Dermatology Unit at the LGI also provide access to experts in the respective fields. Covance in Leeds utilizes the Yorkshire Independent Research Ethics Committee. This committee maintains a two-week turnaround time for study approvals, facilitating swift study starts.
Human Appetite Laboratory (HAL)
The HAL, located within the Leeds CRU, is designed to enable carefully controlled evaluation of appetite and food consumption. Test meals are designed, prepared, and consumed onsite. Specialized equipment, including a multi-frequency bioimpedance machine and hand-held computers, capture body composition measurements and Visual Analog Scale (VAS) data. Quick turnaround for biomarker analysis is available at Covance Laboratories in Harrogate, only 25 kilometres away.
Radiolabeled Studies
Our Leeds clinic is licensed to conduct human radiolabeled studies. These studies are run in conjunction with the metabolism group at Covance Labs in Harrogate, to achieve 24-hour or better turnaround on radiosample analysis. Our in-house pharmacy has the capability to prepare cGMP compliant radiolabeled formulations.
Pharmacometrics Services
Covance's pharmacometrics services encompass the disciplines of data management, statistics, PK/PD analysis, SAS programming and Medical Writing.
Leeds is home to Covance's Pharmacometrics Centre for Europe/Asia. Our team of 70+ dedicated professionals is closely involved with your clinical trial from protocol design to final report. Purchase a full package or only the services you need; the Covance Pharmacometrics team delivers timely, accurate clinical trial data, enabling you to make informed decisions about the safety and tolerability of your compound faster. All data deliverables are produced according to the clients' individual specifications and formats. Dual locations in the US and UK offers the advantage of global time zone differences when urgent turnaround is needed.
Phase IIa
Covance Leeds also has experience conducting proof of concept studies in a variety of patient groups. Whether the study is a continuation of an existing programme of Phase I studies, or managed at a number of external investigator sites, our team of feasibility, project management and CRA professionals are able to recruit, set-up, manage and monitor studies in a timely and cost-effective manner. |
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| Site Capabilities |
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| Some capabilities at our Leeds site include: |
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| Equipment |
Medical Specialists |
Procedure Experience |
- -70°C freezer
- -20°C freezer
- Automated vital sign machines
- Biospace Inbody 720 body composition analyser
- Breathalyser / Intoximeter
- ECG equipment
- Holter monitor
- I-STAT machine for glucose
- IV infusion pumps
- Rigiscan
- Slit lamp
- Spirometry
- Ultrasound
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- Anesthesiologist
- Dermatologist
- Dietician / Nutritionist
- Emergency Medicine
- Endocrinologist
- Geriatrician
- Licensed Pharmacist
- Rheumatologist
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- 24-hour hormone profiling
- Bioimpedance analysis
- Bleeding time
- Bronchial challenge
- Cytokine analysis
- dQTc
- Ex vivo LPS stimulated TNF α production
- Electrocardiogram
- FACS analysis
- Gastric pH measurement
- Glucose tolerance test
- Holter monitoring
- Platelet aggregation
- Telemetry
- Ultrasound
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| Other Covance Clinical Research Units |
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