Clinical Pharmacology (Phase I-IIa)
Honolulu, Hawaii |
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Covance Clinical Research Unit — Honolulu
One Waterfront Plaza
500 Ala Moana Boulevard, Suite 400
Honolulu, Hawaii 96813
808-592-2639 |
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| Site Features |
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The Covance Clinical Research Unit in Honolulu on the island of Oahu was founded in 1990 as Ma Na' Institute. Today, the center occupies a beautiful new 16,000+ square foot purpose-built clinic facility. The 50-bed Phase I facility specializes in first-in-human, Japanese-Caucasian and Chinese-Caucasian bridging, pharmacokinetic, pharmacodynamic, dQT, and radiolabeled studies. The Honolulu site can provide a wide range of client specialty services, and also has an established collaboration with the Honolulu Queen's Medical Center / Hamamatsu PET facility and cyclotron, providing the capability to conduct Phase I PET imaging trials using custom-labeled compounds, state of the art imaging, and Phase I study conduct precision. The site has a large participant database of healthy, special population, and patient volunteers, and is able to enroll a wide range of clinical studies.
Japanese Bridging Studies
Covance Honolulu has been conducting Japanese bridging studies since 2000. The site conducted the first Japanese bridging study in the US, and is recognized as one of the world's authorities on Japanese/ethnic bridging studies. Covance Honolulu has a total active subject database of over 12,000 individuals, which includes a rich database of Japanese volunteers. Asian ethnic concentration on the island of Oahu is far greater than any other U.S. metropolitan area, with nearly 20% of the population of Japanese ancestry. Honolulu is also one of the most visited cities in the world by Japanese tourists and Japanese students. Because of this, the Honolulu clinic has been able to build one of the largest Japanese study recruitment databases outside Japan. The site's diverse recruitment database, which includes both 1st/2nd/3rd generation Japanese and Caucasian volunteers, allows the site to do subject matching according to the specific requirements of many bridging studies. The site has been able to complete many challenging Japanese bridging studies and sponsors have often stated that "such bridging studies could not have been enrolled in Japan".
Microdosing Studies
Microdose studies provide early human PK data in less than half the time and for a fraction of the cost of a traditional IND path. In June 2005, the Honolulu research facility pioneered the application and performed the first microdosing study in the US, which evaluated azidothymidine (AZT) at sub-therapeutic "microdose" concentrates. Since then multiple other microdosing studies have been successfully performed. Covance also has working relationships with the major AMS providers in the world and can provide complete trial conduct services. This experience has earned the Honolulu clinic a leadership position in the conduct of microdose trials. |
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| Site Capabilities |
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| Some capabilities at our Honolulu site include: |
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| Equipment |
Medical Professionals |
Procedure Experience |
- -80°C freezer
- -20°C freezers
- Automated vital sign machines
- Bone density scanner (DEXA)
- Breathalyzer / Intoximeter
- Combustion oxidizer
- ECG machine
- Fume hood (Nuclear lab)
- IV infusion pumps
- Laminar flow hood
- Liquid scintillation counter
- Refrigerated centrifuges
- Slit lamp
- Spirometer
- Ultrasound / TVU
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- Dermatologist
- Dietician
- Emergency Medicine
- Family Practitioner
- Gynecologist
- Internist
- Nephrologist
- Ophthalmologist
- Pharmacist
- Radiologist
- Ultrasound Technologist
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- Bleed time
- Bone densitometry
- Colonoscopy
- CT / MRI
- Echocardiography
- Glucose tolerance
- Holter monitoring
- Mammography
- Microdose
- Pap / endometrial biopsy
- PET imaging
- pQCT
- Punch biopsy
- Radiolabeled / AME
- Spirometry
- Ultrasound / TVU
- X-ray
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| Other Covance Clinical Research Units |
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