| Authors |
Kirkland D., Pfuhler S., Tweats D., Aardema M., Crvi R., Darroudi F., Elhajouji A., Glatt H., Hastwell P., Hayashi M., Kasper P., Kirchner S., Lynch A., Marzin D., Maurici D., Meunier J-R., Müller L, Nohynek G, Parry J., Parry E., Thybaud V., Tice R., van Benthem J., Vanparys P. and White P. |
| Title |
How to reduce false positive results when undertaking in vitro genotoxicity testing and thus avoid unnecessary follow-up animal tests: Report of an ECVAM workshop |
| Citation |
Mutat. Res., 628: 31-55 (2007) |
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| Authors |
Kirkland D., Whitwell J., Deyo J. and Serex T. |
| Title |
Failure of antimony trioxide to induce micronuclei or chromosomal aberrations in rat bone marrow after sub-chronic dosing |
| Citation |
Mutat. Res., 627: 119-128 (2007) |
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| Authors |
Thybaud V., Aardema M., Clements J., Dearfield K., Galloway S., hayashi M., Jacobson-Kram D., Kirkland D., MacGregor J. T., Marzin D., Ohyama W., Schuler M., Suzuki H. and Zeiger E. |
| Title |
Strategy for genotoxicity testing: Hazard identification and risk assessment in relation to in vitro testing |
| Citation |
Mutat. Res., 627: 41-58 (2007) |
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| Authors |
Kirkland D., Hayashi M., Jacobson-Kram D., Kasper P., MacGregor J. T., Müller L. and Uno Y. |
| Title |
Summary of major conclusions from the 4th IWGT |
| Citation |
Mutat. Res., 627: 5-9 (2007) |
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| Authors |
Kirkland D., Hayashi M., Jacobson-Kram D., Kasper P., MacGregor J. T., Müller L. and Uno Y. |
| Title |
The International workshops on Genotoxicity Testing (IWGT): History and achievements |
| Citation |
Mutat. Res., 627: 1-4 (2007) |
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| Authors |
Dufour E. K., Kumaravel T., Nohynek G. J., Kirkland D. and Toutain H. |
| Title |
Clastogenicity, photo-clastogenicity or pseudo-photo-clastogenicity: genotoxic effects of zinc oxide in the dark, in pre-irradiated or simultaneously-irradiated chinese hamster ovary cells |
| Citation |
Mutat. Res., 607: 215-224 (2006) |
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| Authors |
Garrigue J-L., Ballantyne M., Kumaravel T., Lloyd M., Nohynek G. J., Kirkland D. and Toutain H. |
| Title |
In vitro genotoxicity of para-phenylenediamine and its N-monoacetyl or N,N'-diacetyl metabolites |
| Citation |
Mutat. Res., 608: 58-71 (2006) |
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| Authors |
Kirkland D., Aardema M., Müller L. and Hayashi M. |
| Title |
Evaluation of the ability of a battery of 3 in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens. II. Further analysis of mammalian cell results, relative predictivity and tumour profiles |
| Citation |
Mutat. Res. 608: 29-42 (2006) |
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| Authors |
Kirkland D. and Beevers C. |
| Title |
Induction of LacZ mutations in Muta™ Mouse can distinguish carcinogenic from non-carcinogenic analogues of diaminotoluenes and nitronaphthalenes |
| Citation |
Mutat. Res. 608: 88-96 (2006) |
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| Authors |
Baldrick P. |
| Title |
Carcinogenicity evaluation: Comparison of tumor data from dual control groups in the Sprague-Dawley rat |
| Citation |
Toxicologic Pathology, 33: 283-291 (2005) |
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| Authors |
Kirkland D., Aardema M., Henderson L. and Müller L. |
| Title |
Evaluation of the ability of a battery of three in vitro genotoxicity tests to discrimiate rodent carcinogens and non-carcinogens. I. Sensitivity, specificity and relative predictivity |
| Citation |
Mutat. Res., 584: 1-256 (2005) |
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| Authors |
Thompson C., Ferdinandi E., Morley P., Kirkland D. and Proudlock R. |
| Title |
Modified bacterial mutation test procedures for evaluation of peptides and amino-acid containing material |
| Citation |
Mutagenesis, 20: 345-350 (2005) |
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| Authors |
Kirkland D., Henderson L., Marzin D., Müller L., Parry J. M., Speit G., Tweats D. J. and Williams G. M. |
| Title |
Testing strategies in mutagenicity and genetic toxicology: an appraisal of the guidelines of the European Scientific Committee for Cosmetics and Non-Food Products for the evaluation of hair dyes |
| Citation |
Mutat. Res, 588: 88-105 (2005) |
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| Author |
Gibbs A. |
| Title |
Comparison of the specificity and sensitivity of traditional methods for assessment of nephrotoxicity in the rat with metabonomic and proteomic methodologies |
| Citation |
J. Appl. Toxicol., 25(4): 277-295 (2005) |
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| Authors |
Nohynek G. J., Kirkland D., Marzin D., Toutain H., Leclerc-Ribaud C. and Jinnai H. |
| Title |
An assessment of the genotoxicity and human health risk of topical use of kojic acid [5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one] |
| Citation |
Fd. Chem. Toxicol. 42: 93-105 (2004) |
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| Authors |
Marzin D. and Kirkland D. |
| Title |
2-Hydroxy-1,4-naphthoquinone, the natural dye of Henna, is non-genotoxic in the mouse bone marrow micronucleus test and does not produce oxidative DNA damage in Chinese hamster ovary cells |
| Citation |
Mutat. Res., 560: 41-47 (2004) |
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| Authors |
Kirkland D. and Snodin D. |
| Title |
Setting limits for genotoxic impurities in drug substances: Threshold-based and pragmatic approaches. |
| Citation |
Int. J. Pharm. Med., 18: 197-207 (2004) |
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| Authors |
Kasper P., Kirkland D., Leblanc B., Sjöberg P. and Spindler P. |
| Title |
Acceptability of low levels of genotoxic impurities in new drug substances: Conclusions of the Drug Information Association (DIA)/European Medicines Agency (EMEA) Workshop, October 27-28, 2003 in London, UK |
| Citation |
Int. J. Pharm. Med, 18: 221-223 (2004) |
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| Authors |
Spindler P., Silva Lima B., Vidal J-M., Kasper P., Sjöberg P., Olejniczak K., Liminga U., van der Laan J-W., Kirkland D., Newall D. R., Bode G. and Lodola A. |
| Title |
Preclinical Safety Assessment Update |
| Citation |
Drug Information Journal (2004) |
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| Authors |
Hall-Manning T., Spurgeon M., Wolfreys A.M. and Baldrick P. |
| Title |
Safety evaluation of ice-structuring protein (ISP) type III HPLC 12 preparation. Lack of genotoxicity and subchronic toxicity |
| Citation |
Food and Chemical Toxicology, 42(2): 327-339 (2004) |
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| Authors |
Lea L., Hepburn P.A. and Wolfreys A.M. and Baldrick P. |
| Title |
Safety evaluation of phytosterol esters. Part 8. Lack of genotoxicity and subchronic toxicity with phytosterol oxides |
| Citation |
Food and Chemical Toxicology, 42(5): 771-783 (2004) |
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| Authors |
Baldrick P., Richardson D., Wheeler A. W. and Woroniecki S. R. |
| Title |
Safety evaluation of a new allergy vaccine containing the adjuvant Monophosphoryl Lipid A (MPL) for the treatment of grass pollen allergy |
| Citation |
Journal of Applied Toxicology, 24(4): 261-268 (2004) |
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| Author |
Baldrick P. |
| Title |
Developing drugs for pediatric use: a role for juvenile animal studies? |
| Citation |
Regulatory Toxicology and Pharmacology, 39(3): 381-389 (2004) |
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| Author |
Baldrick P. |
| Title |
Toxicokinetics in preclinical evaluation |
| Citation |
Drug Discovery Today, 8: 127-133 (2003) |
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| Author |
Baldrick P. |
| Title |
Biological safety testing of polymers |
| Citation |
Medical Device Technology, pp. 12-15, June 2003 |
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| Authors |
Marshall R., Tricta F., Galanello R., Leoni G., Kirkland D., Minto S. and Spino M. |
| Title |
Chromosomal aberration frequencies in patients with thalassaemia major undergoing therapy with Deferiprone and Deferoxamine in a comparative crossover study |
| Citation |
Mutagenesis, 18: 1-7 (2003) |
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| Authors |
Kirkland D. and Marzin D. |
| Title |
An assessment of the genotoxicity of 2-hydroxy-1,4-naphthoquinone, the natural dye ingredient of Henna |
| Citation |
Mutat. Res., 537: 183-199 (2003) |
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| Author |
Kirkland D. |
| Title |
Reports of the 3rd International Workshop on Genotoxicity Testing (IWGT) June 28-29, 2002, Plymouth, UK. Preface |
| Citation |
Mutat. Res., 540: 119-121 (2003) |
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| Authors |
Kirkland D., Hayashi M., MacGregor J. T., Müller L., Schechtman L. M. and Sofuni T. |
| Title |
Reports of the 3rd International Workshop of Genotoxicity Testing (IWGT), June 28-29, 2002, Plymouth, UK. Summary of major conclusions |
| Citation |
Mutat. Res., 540: 123-125 (2003) |
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| Authors |
Müller L., Blakey D., Dearfield K. L., Galloway S., Guzzie P., Hayashi M., Kasper P., Kirkland D., MacGregor J. T., Parry J. M., Schechtman L., Smith A., Tanaka N., Tweats D. and Yamasaki H. |
| Title |
Strategy for genotoxicity testing and stratification of genotoxicity test results — report on initial activities of the IWGT Expert Group |
| Citation |
Mutat. Res., 540: 177-181 (2003) |
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| Authors |
Weng N., Shou W., Addison T., Maleki S., Jiang X. |
| Title |
Liquid chromatography/tandem mass spectrometry bioanalysis using
normal-phase columns with aqueous/organic mobile phases — a novel
approach of eliminating evaporation and reconstitution steps in 96-well
SPE |
| Citation |
Rapid Comm, Mass Spectrom, 16(20) 2002: 1965-75 |
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| Author |
Kirkland D. |
| Title |
The role of UKEMS in the development of testing
guidelines |
| Citation |
Mutagenesis, 17:451-455 (2002) |
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| Authors |
Baldrick P., Richardson D., Wheeler A. W. |
| Title |
Review of L-tyrosine confirming its safe human use as an adjuvant |
| Citation |
J. Appl. Toxicol., 22: 333-344 (2002) |
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| Author |
Baldrick P. |
| Title |
Safety evaluation of monophosphoryl lipid A (MPL): an immunostimulatory adjuvant |
| Citation |
Regul. Toxicol. Pharmacol., 35: 398-413 (2002) |
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| Author |
MacKenzie I. |
| Title |
Safety Pharmacology Requirements for the Development of Human
Cardiac/Cardiovascular Pharmaceuticals |
| Citation |
Drug Development Research, 55: 73-78 (2002) |
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| Authors |
Hammond T. G., Carlsson L., Davis A. S., Lynch W. G., MacKenzie I., Redfern W. S., Sullivan A. T. and Camm A. J. |
| Title |
Methods of collecting and evaluating nonclinical cardiac electrophysiology data in the pharmaceutical industry: results of an international survey |
| Citation |
Cardiovasc., Res. 49: 741-750 (2001) |
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| Authors |
Workman A. J., MacKenzie I. and Northover B. J. |
| Title |
A KATP opener shortened myocardial reperfusion action potential shortening and arrhythmias |
| Citation |
Eur. J. Pharmac. 419: 73-83 (2001) |
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| Authors |
House, R. V. and Thomas, P. T. |
| Title |
Immunotoxicology: Fundamentals of Preclinical Assessment |
| Citation |
Handbook of Toxicology, Second Edition, M. J. Derelanko and M. A. Hollinger, Ed., CRC Press LLC: Chapter 9, pp. 401-438 (2001) |
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| Author |
Hall, R. L. |
| Title |
Principles of Clinical Pathology for Toxicology Studies |
| Citation |
Principles and Methods of Toxicology, Fourth Edition, A. W. Hayes, Ed., Taylor & Francis, London, pp. 1001-1038, 2001 |
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| Authors |
Bentley, K. S., Kirkland D., Murphy M. and Marshall R. |
| Title |
Evaluation of thresholds for benomyl- and carbendazim-induced aneuploidy in cultured human lymphocytes using fluorescence in situ hybrisdisation |
| Citation |
Mutat. Res., 464(1): 41-51 (2000) |
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| Authors |
Kirkland D., Muller L. |
| Title |
Interpretation of the biological relevance of genotoxicity test results: the importance of thresholds |
| Citation |
Mutat. Res., 464(1): 137-147 (2000) |
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| Authors |
Kapke G. F., Watson G., Sheffler S., Hunt D., Frederick C. |
| Title |
Comparison of the Chiron Quantiplex branched DNA (bDNA) assay and the Abbott Genostics solution hybridization assay for quantification of Hepatitis B viral DNA |
| Citation |
Journal of Viral Hepatitis, 4: 67-75 (1997) |
