ICH Core Battery Tests

End-to-end compliance with ICH S7 Guidelines

These studies are designed to identify the undesirable pharmacodynamic properties of a compound relevant to human safety in three areas — Cardiovascular, Respiratory and the Central Nervous System. 

We partner with you on the following studies:

  • Cardiovascular system
    • chronically instrumented conscious canine, nonhuman primate, and mini pig models using radiotelemetry 
  • Respiratory system
    • rodent whole body and head-out plethysmography
    • arterial blood gas in nonhuman primates
  • Central Nervous System
    • modified Irwin test in rodents and nonhuman primates
    • automated behavioral assessment in nonhuman primates
  • Combination cardiovascular/respiratory
    • anesthetized canine and nonhuman primate models
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