Food & Dietary Supplements
Phytochemicals |
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The terms phytochemicals and phytonutrients have been adopted as descriptors for certain organic components of plants that are thought to promote human health. Unlike the traditional nutrients, these compounds are not "essential" for life from a traditional standpoint but are being increasingly recognized as having beneficial health characteristics. As the popularity of these products has increased with mainstream consumers, the use of a variety of dietary supplements, herbals/botanicals, and functional foods has expanded and resulted in an intense and competitive marketplace. The ability to scientifically substantiate claims for quality, purity, consistency, stability, safety and efficacy is an essential marketing tool and frequently a regulatory requirement. Covance provides the scientific expertise to substantiate claims, enabling you to satisfy the requirements of regulatory agencies and customer demands. In many cases, scientific information about the components of interest is relatively sparse and, as a result, require the development or modification of analytical methods. Covance routinely develops and validates methods for newly identified compounds and modifies methods to optimize analytical performance in unique matrices.
To view and order copies of Covance articles on phytochemicals please visit our Publications page.
Phytosterols
Gas Chromatography
Official Methods of Analysis of AOAC INTERNATIONAL (2000) 17th Ed., AOAC INTERNATIONAL, Gaithersburg, MD, USA, Official Method 994.10. (Modified)
Carotenoids
Beta Carotene
High-performance liquid chromatography
Official Methods of Analysis of AOAC INTERNATIONAL (2000) 17th Ed., AOAC
INTERNATIONAL, Gaithersburg, MD, USA, Official Method 941.15. (Modified)
Quackenbush, F. W., Journal of Liquid Chromatography, 10: 643-653, (1987). (Modified)
Alpha and Beta Carotene
High-performance liquid chromatography
Official Methods of Analysis of AOAC INTERNATIONAL (2000) 17th Ed., AOAC
INTERNATIONAL, Gaithersburg, MD, USA, Official Method 941.15. (Modified)
Quackenbush, F. W., Journal of Liquid Chromatography, 10: 643-653, (1987). (Modified)
Lycopene
High-performance liquid chromatography
Official Methods of Analysis of AOAC INTERNATIONAL (2000) 17th Ed., AOAC
INTERNATIONAL, Gaithersburg, MD, USA, Official Method 941.15. (Modified)
Quackenbush, F. W., Journal of Liquid Chromatography, 10: 643-653, (1987). (Modified)
Lutein
High-performance liquid chromatography
Official Methods of Analysis of AOAC INTERNATIONAL (2000) 17th Ed., AOAC
INTERNATIONAL, Gaithersburg, MD, USA, Official Method 941.15. (Modified)
Quackenbush, F. W., Journal of Liquid Chromatography, 10: 643-653, (1987). (Modified)
Zeaxanthin
High-performance liquid chromatography
Official Methods of Analysis of AOAC INTERNATIONAL (2000) 17th Ed., AOAC
INTERNATIONAL, Gaithersburg, MD, USA, Official Method 941.15. (Modified)
Quackenbush, F. W., Journal of Liquid Chromatography, 10: 643-653, (1987). (Modified)
Tocotrienols
High-performance liquid chromatography
Cort, W. M., Vincente, T. S., Waysek, E. H., and Williams, B. D., Journal of Association of Official Analytical Chemists (modified), 63: 1258-1261 (1980).
Agricultural Food Chemistry (modified), 31: 1330-1333 (1983).
Speek, A. J., Schijver, J., and Schreurs, W. H. P., Journal of Food Science (modified), 50: 121-124 (1985).
McMurray, C. H., Blanchflower, W. J., and Rice D. A., Journal of the Association of the Official Analytical Chemists (modified), 63: 1258-1261 (1980)
Isoflavones
High-performance liquid chromatography
Seo, A. and Morr, C.V., "Improved High-Performance Liquid Chromatographic Analysis of Phenolic Acids and Isoflavonoids from Soybean Protein Products," J. Agric. Food Chem., 32(3): pp 530-533, 1984
Petterson, H. and Kiessling, K., JAOAC, 67(3): pp 503-506, 1984
Flavonoids
Gas chromatography
Bankova, V., Journal of Chromatography, Vol 607, (1992), pp 150-153, modified
Omega-3 Fatty Acids
Gas chromatography
American Oil Chemists' Society, 'Ce 1b-89 Fatty Acid Composition by GLC Marine Oils' (modified), Official Methods and Recommended Practices of the AOCS, Fifth Ed., American Oil Chemists' Society, Champaign, IL (1997)
Phospholipids
Atomic absorption
Please contact a Client Service Coordinator
Nucleosides
High-performance liquid chromatography
Olivartes, J. and Verdys, M., "Isocratic High-Performance Liquid Chromatographic Method for Studying the Metabolism of Blood Plasma Pyrimidine Nucleosides and Bases: Concentration and Radioactivity Measurements" Journal of Chromatography, 434, (1988). (Modified)
Nucleotides
High-performance liquid chromatography
Paubert-Braquet M., Dupont CH. Paoletti R (EDS): Foods, Nutrition and Immunity, "Quantification of Nucleotides in Human Milk and their effects on Cytokine Production by Murine Fibroblasts, J774A1 Macrophages and Human Monocytes, "DYN Nutr Res. Basel, Karger, 1:22-34 (1992). (Modified)
Chondroitin Sulfate
High performance liquid chromatography
Please contact Client Service Coordinator
SAMEe (S-adenosylmethionine)
High performance liquid chromatography
d'Avignon, A., Reepmeyer, J., Revelle, L., Zerfine, C., "Stability-Indicaton Proton Nuclear Magnetic Resonance Spectroscopic Method for Determination of S-Adenosyl-L-Methionine in Tablets", Vol. 78, No. 2: p. 353 (1995)
Edwards, R., "Determination of S-Adenosyl-L-Methionine and S-Adenosyl-L-Homocysteine in Plants", Vol. 6, pp. 25-30 (1995)
Glucosamine
High performance liquid chromatography
Dionex Chromatography Database 4.2.0, Record 755
Creatine
High performance liquid chromatography
Analytical Biochemistry 214, pp. 278-283 (1993)
Coenzyme Q-10 (ubiquinone)
High performance liquid chromatography
Journal of Chromatography, 606, (1992), 272-726 (Modified)
Ribose
High performance liquid chromatography
Official Methods of Analysis of AOAC INTERNATIONAL (2000) 17th Ed., AOAC INTERNATIONAL, Gaithersburg, MD, USA, Official Method 982.14. (Modified)
Ferulic Acid/Coumaric Acid
High performance liquid chromatography
Hagerman, A.E., Nicholson, R.L., "High-Performance Liquid Chromatographic Determination of Hydroxycinnamic Acids in Maize Mesocotyl," Journal of Agricultural and Food Chemistry, 30 (No. 6): 1098-1102, (1982), Modified
Caffeic Acid
High performance liquid chromatography
Hagerman, A.E., Nicholson, R.L., "High-Performance Liquid Chromatographic Determination of Hydroxycinnamic Acids in Maize Mesocotyl," Journal of Agricultural and Food Chemistry, 30 (No. 6): 1098-1102, (1982), Modified
Carnosic Acid
High performance liquid chromatography
Please contact Client Service Coordinator |
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